Modulation of taste responsiveness and food preference by obesity and weight loss.
Modulation of taste responsiveness and food preference by obesity and weight loss.
复制标题
DOI：
10.1016/j.physbeh.2012.04.004
复制
发表时间：
2012-11-05
影响因子：
2.9
通讯作者：
Zheng, Huiyuan
中科院分区：
文献类型：
--
作者：
Berthoud, Hans-Rudolf;Zheng, Huiyuan
关键词：
美味的食物会导致暴饮暴食，这几乎是一个被放弃的结论，它也是目前肥胖症流行的一个重要因素--甚至有关于食物成瘾的讨论。然而，味觉和肥胖之间的因果关系还远不清楚。正如这里讨论的，有大量证据表明肥胖者的味觉敏感度、味觉引导的喜好和欲望以及神经奖励处理都发生了变化，但尚不清楚这些特征是否会导致肥胖，或者肥胖是否会继而改变这些功能。在人类和动物模型上进行的卡路里限制诱导的体重减轻和减肥手术的研究表明，至少部分由肥胖引起的改变是可逆的，因此代表了肥胖状态的次要影响。因此，遗传和非遗传倾向以及味觉和奖赏功能的获得性改变似乎共同作用，加剧了适口性诱导的吞噬。此外，适口性通常与高能量含量有关，这进一步挑战了能量平衡调节。由肥胖状态、体重减轻和减肥手术引起的这些改变的机制在很大程度上仍未被探索。更好的了解将有助于制定战略，促进更健康的饮食，预防肥胖和随之而来的慢性病风险。
Palatable foods lead to overeating, and it is almost a forgone conclusion that it is also an important contributor to the current obesity epidemic - there is even talk about food addiction. However, the cause-effect relationship between taste and obesity is far from clear. As discussed here, there is substantial evidence for altered taste sensitivity, taste-guided liking and wanting, and neural reward processing in the obese, but it is not clear whether such traits cause obesity or whether obesity secondarily alters these functions. Studies with calorie restriction-induced weight loss and bariatric surgery in humans and animal models suggest that at least some of the obesity-induced alterations are reversible and consequently represent secondary effects of the obese state. Thus, both genetic and non-genetic predisposition and acquired alterations in taste and reward functions appear to work in concert to aggravate palatability-induced hyperphagia. In addition, palatability is typically associated with high energy content, further challenging energy balance regulation. The mechanisms responsible for these alterations induced by the obese state, weight loss, and bariatric surgery, remain largely unexplored. Better understanding would be helpful in designing strategies to promote healthier eating and prevention of obesity and the accompanying chronic disease risks.
登录
查看更多内容
DOI：
10.1523/jneurosci.3262-11.2011
发表时间：
2011-10-12
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Dossat AM;Lilly N;Kay K;Williams DL
通讯作者：
Williams DL
影响因子：
7.1
作者：
Cornier, Marc-Andre;Von Kaenel, Sandra S.;Tregellas, Jason R.
通讯作者：
Tregellas, Jason R.
影响因子：
16.2
作者：
Borgland, SL;Taha, SA;Bonci, A
通讯作者：
Bonci, A
影响因子：
2.9
作者：
Bueter, M.;Miras, A. D.;le Roux, C. W.
通讯作者：
le Roux, C. W.
影响因子：
5.4
作者：
Burton, Pat;Smit, Hendrik J.;Lightowler, Helen J.
通讯作者：
Lightowler, Helen J.