Association of IL18 genetic polymorphisms with increased risk of Biliary atresia susceptibility in Southern Chinese children.
Association of IL18 genetic polymorphisms with increased risk of Biliary atresia susceptibility in Southern Chinese children.
复制标题
IL18 基因多态性与中国南方儿童胆道闭锁易感性风险增加的关系。
DOI：
10.1016/j.gene.2018.07.071
复制
发表时间：
2018-11
期刊：
影响因子：
3.5
通讯作者：
Zhang R
中科院分区：
文献类型：
--
作者：
Liang J;Wen Z;Zhao J;Liang Q;Liu T;Xia H;Zhang Y;Zhang R
胆道闭锁（BA）具有复杂的遗传病因，其特点是Kasai手术后不同程度的肝纤维化和对胆管的免疫反应。il -18作为胆道闭锁中两种最重要的炎症细胞（T细胞和NK细胞）的激活剂，在BA患者中显著升高。本研究旨在探讨白细胞介素18（IL-18）与BA易感性的关系。我们在中国南方一个由506例病例和1473例对照组成的人群中检测了三种多态性（rss549908、rs187238和rs1946518 inIL-18）与BA易感性的关系。SNP rs187238和rs1946518与BA相关。有趣的是，我们还通过逻辑回归和多因素降维（MDR）分析发现，snp rs187238和rs1946518之间的基因内协同上位增加了BA的风险。本研究首次提供了直接证据支持IL-18是中国南方儿童该病的易感基因。
Biliary atresia (BA) has complex genetic etiology, characterized by different levels of hepatic fibrosis after the Kasai procedure and immune responses to the bile duct. As an activator of the two most important inflammatory cells in Biliary atresia (T cells and NK cells),IL-18is significantly increased in BA patients. This study aims to investigate the association of Interleukin 18(IL-18) with the susceptibility to BA. We examined the association of three polymorphisms (rs549908, rs187238 and rs1946518 inIL-18) and BA susceptibility in a Southern Chinese population composed of 506 cases and 1473 controls. SNP rs187238 and rs1946518 were identified as associated with BA. Interestingly, we also observed that the intragenic synergistic epistasis between SNPs rs187238 and rs1946518 boosting the risk to BA by logistic regression and Multifactor dimensionality reduction (MDR) analysis. This study provides for the first time a direct evidence to support IL-18 as a susceptibility gene for the disease in southern Chinese children.
登录
查看更多内容
影响因子：
2.4
作者：
Davenport, M;Gonde, C;Howard, ER
通讯作者：
Howard, ER
影响因子：
2.4
作者：
N. Urushihara;H. Iwagaki;T. Yagi;H. Kohka;K. Kobashi;Y. Morimoto;T. Yoshino;T. Tanimoto;M. Kurimo
通讯作者：
N. Urushihara;H. Iwagaki;T. Yagi;H. Kohka;K. Kobashi;Y. Morimoto;T. Yoshino;T. Tanimoto;M. Kurimo
DOI：
10.1159/000371694
发表时间：
2015
期刊：
Digestive diseases (Basel, Switzerland)
影响因子：
--
作者：
Mezina A;Karpen SJ
通讯作者：
Karpen SJ
影响因子：
5.8
作者：
Hahn, LW;Ritchie, MD;Moore, JH
通讯作者：
Moore, JH
DOI：
10.1097/mpg.0b013e3182111b9b
发表时间：
2011-05
影响因子：
2.9
作者：
Hung-Chang Lee;Tzu-yang Chang;C. Yeung;W. Chan;Chuen-Bin Jiang;H. Chan;Wei-Fang Chen;Horng-Woei Yang;Marie Lin;Yann-Jinn Lee
通讯作者：
Hung-Chang Lee;Tzu-yang Chang;C. Yeung;W. Chan;Chuen-Bin Jiang;H. Chan;Wei-Fang Chen;Horng-Woei Yang;Marie Lin;Yann-Jinn Lee