Multimodal Imaging of Microvascular Abnormalities in Retinal Vein Occlusion.
Multimodal Imaging of Microvascular Abnormalities in Retinal Vein Occlusion.
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DOI：
10.3390/jcm10030405
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发表时间：
2021-01-21
影响因子：
3.9
通讯作者：
Ogura Y
中科院分区：
文献类型：
--
作者：
Hirano Y;Suzuki N;Tomiyasu T;Kurobe R;Yasuda Y;Esaki Y;Yasukawa T;Yoshida M;Ogura Y
光学相干断层扫描（OCT）和OCT血管造影（OCTA）等眼部成像技术取得了显著进展。在这些体内成像模式中，最近先进的OCT技术提供了高分辨率图像，例如组织学成像，能够对每个视网膜层进行解剖分析，包括光感受器层。最近开发的OCTA还可以三维可视化血管网络，从而更好地了解视网膜深部毛细血管层。此外，体外分析显示，包括血管内皮生长因子（VEGF）在内的炎性细胞因子水平升高，并与视网膜静脉闭塞（RVO）眼黄斑水肿（ME）的严重程度相关。此外，多种模式的结合可以加深对病理的理解。在治疗方面，玻璃体内注射抗vegf药物可以快速解决ME，并且比RVO的常规治疗方法更好地改善视力。因此，治疗RVO的检查和治疗技术发展迅速。在本文中，我们回顾了RVO眼部的多模态成像和治疗策略，希望它能更好地理解病理并导致新疗法的发展。
The technologies of ocular imaging modalities such as optical coherence tomography (OCT) and OCT angiography (OCTA) have progressed remarkably. Of these in vivo imaging modalities, recently advanced OCT technology provides high-resolution images, e.g., histologic imaging, enabling anatomical analysis of each retinal layer, including the photoreceptor layers. Recently developed OCTA also visualizes the vascular networks three-dimensionally, which provides better understanding of the retinal deep capillary layer. In addition, ex vivo analysis using autologous aqueous or vitreous humor shows that inflammatory cytokine levels including vascular endothelial growth factor (VEGF) are elevated and correlated with the severity of macular edema (ME) in eyes with retinal vein occlusion (RVO). Furthermore, a combination of multiple modalities enables deeper understanding of the pathology. Regarding therapy, intravitreal injection of anti-VEGF drugs provides rapid resolution of ME and much better visual improvements than conventional treatments in eyes with RVO. Thus, the technologies of examination and treatment for managing eyes with RVO have progressed rapidly. In this paper, we review the multimodal imaging and therapeutic strategies for eyes with RVO with the hope that it provides better understanding of the pathology and leads to the development of new therapies.
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影响因子：
13.7
作者：
Christoffersen, NLB;Larsen, M
通讯作者：
Larsen, M
影响因子：
13.7
作者：
Browning, DJ;Scott, AQ;Zhang, ZY
通讯作者：
Zhang, ZY
影响因子：
4.1
作者：
ASHTON, N
通讯作者：
ASHTON, N
影响因子：
--
作者：
BLANKENSHIP, GW;OKUN, E
通讯作者：
OKUN, E
DOI：
10.1136/bjo.47.9.521
发表时间：
1963-09-01
期刊：
The British journal of ophthalmology
影响因子：
--
作者：
ASHTON, N
通讯作者：
ASHTON, N