Mechanisms of airway hyper-responsiveness in asthma: the past, present and yet to come.
Mechanisms of airway hyper-responsiveness in asthma: the past, present and yet to come.
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DOI：
10.1111/cea.12506
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发表时间：
2015-04
期刊：
影响因子：
--
通讯作者：
Irvin CG
中科院分区：
文献类型：
--
作者：
Chapman DG;Irvin CG
Airway hyperresponsiveness (AHR) has long been considered a cardinal feature of asthma. The development of the measurement of AHR forty years ago initiated many important contributions to our understanding of asthma and other airway diseases. However, our understanding of AHR in asthma remains complicated by the multitude of potential underlying mechanisms which in reality are likely to have different contributions amongst individual patients. Therefore the present review will discuss the current state of understanding of the major mechanisms proposed to contribute to AHR and highlight the way in which AHR testing is beginning to highlight distinct abnormalities associated with clinically relevant patient populations. In doing so we aim to provide a foundation by which future research can begin to ascribe certain mechanisms to specific patterns of bronchoconstriction and subsequently match phenotypes of bronchoconstriction with clinical phenotypes. We believe that this approach is not only within our grasp but will lead to improved mechanistic understanding of asthma phenotypes and hopefully better inform the development of phenotype-targeted therapy.
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