Development and clinical evaluation of multiple investigational monovalent DENV vaccines to identify components for inclusion in a live attenuated tetravalent DENV vaccine.
Development and clinical evaluation of multiple investigational monovalent DENV vaccines to identify components for inclusion in a live attenuated tetravalent DENV vaccine.
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DOI：
10.1016/j.vaccine.2011.07.023
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发表时间：
2011-09-23
期刊：
影响因子：
5.5
通讯作者：
Whitehead, Stephen S.
中科院分区：
文献类型：
--
作者：
Durbin, Anna P.;Kirkpatrick, Beth D.;Pierce, Kristen K.;Schmidt, Alexander C.;Whitehead, Stephen S.
美国国立卫生研究院国家过敏和传染病研究所的传染病实验室十多年来一直致力于开发一种安全、有效和负担得起的四价登革减毒活疫苗（LATV）。已经在SCID-HuH-7小鼠和恒河猴中评估了许多重组单价DENV疫苗候选物，以鉴定具有合适减毒表型的那些候选物。此外，还确定了这些候选物在伊蚊中感染和传播的能力。选择在SCID-HuH-7小鼠、恒河猴和蚊子中适当减毒的那些候选物用于在人类中进一步评估。本综述将描述针对每种DENV血清型的多种候选疫苗的产生，这些候选疫苗的临床前和临床评价，以及选择合适的候选疫苗纳入LATV登革热疫苗的过程。
The Laboratory of Infectious Diseases at the National Institute of Allergy and Infectious Diseases, National Institutes of Health has been engaged in an effort to develop a safe, efficacious, and affordable live attenuated tetravalent dengue vaccine (LATV) for more than ten years. Numerous recombinant monovalent DENV vaccine candidates have been evaluated in the SCID-HuH-7 mouse and in rhesus macaques to identify those candidates with a suitable attenuation phenotype. In addition, the ability of these candidates to infect and disseminate in Aedes mosquitoes had also been determined. Those candidates that were suitably attenuated in SCID-HuH-7 mice, rhesus macaques, and mosquitoes were selected for further evaluation in humans. This review will describe the generation of multiple candidate vaccines directed against each DENV serotype, the preclinical and clinical evaluation of these candidates, and the process of selecting suitable candidates for inclusion in a LATV dengue vaccine.
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DOI：
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发表时间：
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影响因子：
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