The ankle-brachial index and incident cardiovascular events in the MESA (Multi-Ethnic Study of Atherosclerosis).
The ankle-brachial index and incident cardiovascular events in the MESA (Multi-Ethnic Study of Atherosclerosis).
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DOI：
10.1016/j.jacc.2010.04.060
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发表时间：
2010-10-26
影响因子：
24
通讯作者：
Shea, Steven
中科院分区：
文献类型：
--
作者：
Criqui, Michael H.;McClelland, Robyn L.;McDermott, Mary M.;Allison, Matthew A.;Blumenthal, Roger S.;Aboyans, Victor;Ix, Joachim H.;Burke, Gregory L.;Liu, Kaing;Shea, Steven
关键词：
本研究的目的是检查多种族队列中低和高踝臂指数 (ABI) 与心血管事件的关联。踝臂指数 (ABI) 异常，无论是低还是高，都与心血管疾病 (CVD) 风险升高相关。然而，目前尚不清楚这种关联在不同种族群体中是否一致，以及它是否独立于新的生物标志物和亚临床动脉粥样硬化 CVD 的其他指标。美国六个现场中心的 6647 名非西班牙裔白人、非裔美国人、西班牙裔和中国男性和女性，年龄 45-84 岁，来自自由生活人群，基线时没有临床 CVD，对传统和较新的生物标志物风险因素以及亚临床 CVD（包括 ABI）进行了广泛的测量。 CVD 事件定义为冠状动脉疾病、中风或其他动脉粥样硬化性 CVD 死亡，是在平均 5.3 年的随访期内确定的。低 (<1.00) 和高 (≥ 1.40) ABI 均与 CVD 事件相关。特定性别和特定种族的分析显示出一致的结果。对传统和新型生物标志物 CVD 风险因素进行调整后，低 ABI 的风险比为 1.77 (p<.001)，高 ABI 的风险比为 1.85 (p=.050)，并且 ABI 显着改善了风险辨别能力。对冠状动脉钙评分、颈总动脉和颈内动脉内膜中层厚度以及主要心电图异常的进一步调整仅适度减弱了这些风险比。在这项研究中，低 ABI 和高 ABI 都与无已知 CVD 的人的 CVD 风险升高相关，独立于标准和新的风险因素，也独立于亚临床 CVD 的其他测量方法。进一步的研究应该解决在目标人群中测量 ABI 的成本效益问题。
The purpose of this study was to examine the association of both a low and a high ankle-brachial index (ABI) with incident cardiovascular events in a multi-ethnic cohort. Abnormal ankle-brachial indices (ABIs), both low and high, are associated with elevated cardiovascular disease (CVD) risk. However, it is unknown whether this association is consistent across different ethnic groups, and whether it is independent of both newer biomarkers and other measures of subclinical atherosclerotic CVD. 6647 non-Hispanic white, African-American, Hispanic, and Chinese men and women aged 45–84 years from free-living populations in six United States field centers and free of clinical CVD at baseline had extensive measures of traditional and newer biomarker risk factors, and measures of subclinical CVD, including the ABI. Incident CVD, defined as coronary disease, stroke, or other atherosclerotic CVD death, was determined over a mean follow-up of 5.3 years. Both a low (<1.00) and a high (≥ 1.40) ABI were associated with incident CVD events. Gender- specific and ethnic-specific analyses showed consistent results. Hazard ratios were 1.77 (p<.001) for a low and 1.85 (p=.050) for a high ABI after adjustment for both traditional and newer biomarker CVD risk factors, and the ABI significantly improved risk discrimination. Further adjustment for coronary artery calcium score, common and internal carotid intimal medial thickness, and major ECG abnormalities only modestly attenuated these hazard ratios. In this study both a low and a high ABI were associated with elevated CVD risk in persons free of known CVD, independent of standard and novel risk factors, and independent of other measures of subclinical CVD. Further research should address the cost-effectiveness of measuring the ABI in targeted population groups.
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影响因子：
120.7
作者：
Fowkes, F. G. R.;Murray, G. D.;Butcher, I.;Heald, C. L.;Lee, R. J.;Chambless, L. E.;Folsom, A. R.;Hirsch, A. T.;Dramaix, M.;deBacker, G.;Wautrecht, J-C.;Kornitzer, M.;Newman, A. B.;Cushman, M.;Sutton-Tyrrell, K.;Lee, A. J.;Price, J. F.;d'Agostino, R. B.;Murabito, J. M.;Norman, P. E.;Jamrozik, K.;Curb, J. D.;Masaki, K. H.;Rodriquez, B. L.;Dekker, J. M.;Bouter, L. M.;Heine, R. J.;Nijpels, G.;Stehouwer, C. D. A.;Ferrucci, L.;McDermott, M. M.;Stoffers, H. E.;Hooi, J. D.;Knottnerus, J. A.;Ogren, M.;Hedblad, B.;Witteman, J. C.;Breteler, M. M. B.;Hunink, M. G. M.;Hofman, A.;Criqui, M. H.;Langer, R. D.;Fronek, A.;Hiatt, W. R.;Hamman, R.;Resnick, H. E.;Guralnik, J.;McDermott, M. M.
通讯作者：
McDermott, M. M.
DOI：
10.1016/j.ejvs.2008.01.013
发表时间：
2008-06-01
影响因子：
5.7
作者：
Suominen, V.;Rantanen, T.;Salenius, J.
通讯作者：
Salenius, J.
影响因子：
37.8
作者：
Cook, Nancy R.
通讯作者：
Cook, Nancy R.
影响因子：
158.5
作者：
Detrano, Robert;Guerci, Alan D.;Kronmal, Richard A.
通讯作者：
Kronmal, Richard A.
DOI：
10.1016/0735-1097(90)90282-t
发表时间：
1990-03-15
影响因子：
24
作者：
AGATSTON, AS;JANOWITZ, WR;DETRANO, R
通讯作者：
DETRANO, R