Interpreting scan data acquired from multiple scanners: a study with Alzheimer's disease.
Interpreting scan data acquired from multiple scanners: a study with Alzheimer's disease.
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DOI：
10.1016/j.neuroimage.2007.09.066
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发表时间：
2008-02-01
期刊：
影响因子：
5.7
通讯作者：
Frackowiak RS
中科院分区：
文献类型：
--
作者：
Stonnington CM;Tan G;Klöppel S;Chu C;Draganski B;Jack CR Jr;Chen K;Ashburner J;Frackowiak RS
利用来自多台扫描仪的MRI衍生测量的大型多站点研究提供了通过汇集数据来推进研究的机会。另一方面，目前还不清楚不同扫描仪和升级所引入的潜在混淆是否会降低任何结果的完整性。尽管存在出于校准和质量控制目的的扫描仪差异研究，但当前文献缺乏描述多扫描仪数据分析的研究，这些研究涉及扫描仪与感兴趣效应的相互作用。我们调查了136名受试者的数据集，其中62名轻度至中度阿尔茨海默病患者和74名认知正常的老年对照，来自一个中心的MRI扫描，这些扫描是在10年内用6种不同的扫描仪和多次升级获得的。我们使用全脑体素分析来评估6种不同扫描仪的扫描效果、疾病效果以及扫描仪和疾病的相互作用。疾病对患者的影响显示内侧颞叶灰质的预期显着减少。扫描仪的差异远小于组间的差异，仅在丘脑中有显著性。扫描仪与疾病组之间无显著交互作用。我们描述了得出我们的结果没有被扫描仪差异混淆的结论的基本原理。其他多扫描仪数据集中的类似分析可用于证明在需要时合并数据的合理性，例如罕见疾病研究或多中心设计。
Large, multi-site studies utilizing MRI-derived measures from multiple scanners present an opportunity to advance research by pooling data. On the other hand, it remains unclear whether or not the potential confound introduced by different scanners and upgrades will devalue the integrity of any results. Although there are studies of scanner differences for the purpose of calibration and quality control, the current literature is devoid of studies that describe the analysis of multi-scanner data with regard to the interaction of scanner(s) with effects of interest. We investigated a data-set of 136 subjects, 62 patients with mild to moderate Alzheimer's disease and 74 cognitively normal elderly controls, with MRI scans from one center that were acquired over 10 years with 6 different scanners and multiple upgrades over time. We used a whole-brain voxel-wise analysis to evaluate the effect of scanner, effect of disease, and the interaction of scanner and disease for the 6 different scanners. The effect of disease in patients showed the expected significant reduction of grey matter in the medial temporal lobe. Scanner differences were substantially less than the group differences and only significant in the thalamus. There was no significant interaction of scanner with disease group. We describe the rationale for concluding that our results were not confounded by scanner differences. Similar analyses in other multi-scanner data-sets could be used to justify the pooling of data when needed, such as in studies of rare disorders or in multi-center designs.
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DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
DOI：
10.1097/01.rmr.0000245457.98029.e1
发表时间：
2005-12-01
期刊：
Topics in magnetic resonance imaging : TMRI
影响因子：
--
作者：
Whitwell, Jennifer L;Jack, Clifford R Jr
通讯作者：
Jack, Clifford R Jr
影响因子：
5.7
作者：
Jovicich, J;Czanner, S;Dale, A
通讯作者：
Dale, A
影响因子：
4.8
作者：
Littmann, Arne;Jens, Guehring;Stiehl, Hans-Siegfried
通讯作者：
Stiehl, Hans-Siegfried
影响因子：
5.7
作者：
Ashburner, J;Friston, KJ
通讯作者：
Friston, KJ