The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Obesity and Cardiovascular Disease.
The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Obesity and Cardiovascular Disease.
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DOI：
10.3390/molecules21091172
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发表时间：
2016-09-03
期刊：
影响因子：
--
通讯作者：
Sodhi K
中科院分区：
文献类型：
--
作者：
Srikanthan K;Shapiro JI;Sodhi K
Na/K-ATP酶因其离子泵功能而被广泛研究，但在过去的几十年中，已被鉴定为支架和信号蛋白。最初发现强心类固醇（CTS）通过Na/K-ATP酶介导信号转导并导致活性氧（ROS）的产生，活性氧也能够启动信号级联。然而，近年来，这种Na/K-ATP酶/ROS放大环已被证明在氧化应激相关疾病状态中具有重要意义，包括肥胖、动脉粥样硬化、心力衰竭、尿毒症性心肌病和高血压。这种新的氧化应激信号通路的发现对上述病症和其他植根于ROS的病症具有显著的治疗潜力。
Na/K-ATPase has been extensively studied for its ion pumping function, but, in the past several decades, has been identified as a scaffolding and signaling protein. Initially it was found that cardiotonic steroids (CTS) mediate signal transduction through the Na/K-ATPase and result in the generation of reactive oxygen species (ROS), which are also capable of initiating the signal cascade. However, in recent years, this Na/K-ATPase/ROS amplification loop has demonstrated significance in oxidative stress related disease states, including obesity, atherosclerosis, heart failure, uremic cardiomyopathy, and hypertension. The discovery of this novel oxidative stress signaling pathway, holds significant therapeutic potential for the aforementioned conditions and others that are rooted in ROS.
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