Integrative genomic profiling of human prostate cancer.
Integrative genomic profiling of human prostate cancer.
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DOI：
10.1016/j.ccr.2010.05.026
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发表时间：
2010-07-13
期刊：
影响因子：
50.3
通讯作者：
Gerald WL
中科院分区：
文献类型：
--
作者：
Taylor BS;Schultz N;Hieronymus H;Gopalan A;Xiao Y;Carver BS;Arora VK;Kaushik P;Cerami E;Reva B;Antipin Y;Mitsiades N;Landers T;Dolgalev I;Major JE;Wilson M;Socci ND;Lash AE;Heguy A;Eastham JA;Scher HI;Reuter VE;Scardino PT;Sander C;Sawyers CL;Gerald WL
前列腺癌基因组的注释为可能影响疾病理解和治疗的发现提供了基础。对218例前列腺癌肿瘤的DNA拷贝数、mRNA表达和聚焦外显子重测序的一致性评估表明，核受体辅激活因子NCOA 2在约11%的肿瘤中为癌基因。此外，雄激素驱动的TMPRSS 2-ERG融合与染色体3 p14处先前未识别的前列腺特异性缺失相关，该缺失暗示FOXP 1、RYBP和SHQ 1是潜在的协同肿瘤抑制因子。来自原发性肿瘤的DNA拷贝数数据显示，拷贝数改变有力地定义了Gleason评分所实现的低风险和高风险疾病的集群。这些患者的基因组和临床结果数据现在作为公共资源提供。
Annotation of prostate cancer genomes provides a foundation for discoveries that can impact disease understanding and treatment. Concordant assessment of DNA copy number, mRNA expression, and focused exon resequencing in 218 prostate cancer tumors identified the nuclear receptor coactivator NCOA2 as an oncogene in ~11 percent of tumors. Additionally, the androgen-driven TMPRSS2-ERG fusion was associated with a previously unrecognized, prostate-specific deletion at chromosome 3p14 that implicates FOXP1, RYBP and SHQ1 as potential cooperative tumor suppressors. DNA copy-number data from primary tumors revealed that copy-number alterations robustly define clusters of low- and high-risk disease beyond that achieved by Gleason score. The genomic and clinical outcome data from these patients is now made available as a public resource.
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影响因子：
30.8
作者：
Carver, Brett S.;Tran, Jennifer;Gopalan, Anuradha;Chen, Zhenbang;Shaikh, Safa;Carracedo, Arkaitz;Alimonti, Andrea;Nardella, Caterina;Varmeh, Shohreh;Scardino, Peter T.;Cordon-Cardo, Carlos;Gerald, William;Pandolfi, Pier Paolo
通讯作者：
Pandolfi, Pier Paolo
影响因子：
64.8
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影响因子：
11.2
作者：
Agoulnik, IU;Vaid, A;Weigel, NL
通讯作者：
Weigel, NL
影响因子：
45.3
作者：
Cooperberg, MR;Moul, JW;Carroll, PR
通讯作者：
Carroll, PR
影响因子：
4.4
作者：
He, WW;Sciavolino, PJ;Carter, KC
通讯作者：
Carter, KC