Regulation of metabolism: the circadian clock dictates the time.
Regulation of metabolism: the circadian clock dictates the time.
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DOI：
10.1016/j.tem.2011.10.005
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发表时间：
2012-01
影响因子：
10.9
通讯作者：
Sassone-Corsi, Paolo
中科院分区：
文献类型：
--
作者：
Sahar, Saurabh;Sassone-Corsi, Paolo
昼夜节律以约24小时的周期发生，并调节广泛的代谢和生理功能。越来越多的流行病学和遗传学证据表明，昼夜节律的破坏可能与许多病理状况直接相关，包括睡眠障碍、抑郁症、代谢综合征和癌症。有趣的是，已经发现构成生物钟机制的许多分子齿轮与细胞代谢的调节器建立功能性相互作用。虽然生物钟调节多种代谢途径，但代谢物的可用性和摄食行为可以反过来调节生物钟。对昼夜节律和细胞代谢的这种相互调节的深入理解可以为针对特定代谢紊乱的治疗干预的发展提供见解。
Circadian rhythms occur with a periodicity of about 24 hours and regulate a wide array of metabolic and physiologic functions. Accumulating epidemiological and genetic evidence indicates that disruption of circadian rhythms can be directly linked to many pathological conditions, including sleep disorders, depression, metabolic syndrome and cancer. Intriguingly, a number of molecular gears constituting the clock machinery have been found to establish functional interplays with regulators of cellular metabolism. While the circadian clock regulates multiple metabolic pathways, metabolite availability and feeding behavior can in turn regulate the circadian clock. An in-depth understanding of this reciprocal regulation of circadian rhythms and cellular metabolism may provide insights in the development of therapeutic intervention against specific metabolic disorders.
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影响因子：
64.8
作者：
Alenghat, Theresa;Meyers, Katherine;Mullican, Shannon E.;Leitner, Kirstin;Adeniji-Adele, Adetoun;Avila, Jacqueline;Bucan, Maja;Ahima, Rexford S.;Kaestner, Klaus H.;Lazar, Mitchell A.
通讯作者：
Lazar, Mitchell A.
影响因子：
9.2
作者：
Akhtar, RA;Reddy, AB;Kyriacou, CP
通讯作者：
Kyriacou, CP
DOI：
10.1126/science.1198125
发表时间：
2011-03-11
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Feng D;Liu T;Sun Z;Bugge A;Mullican SE;Alenghat T;Liu XS;Lazar MA
通讯作者：
Lazar MA
影响因子：
7.7
作者：
De Bacquer, D.;Van Risseghem, M.;Braeckman, L.
通讯作者：
Braeckman, L.
影响因子：
29
作者：
Grimaldi B;Bellet MM;Katada S;Astarita G;Hirayama J;Amin RH;Granneman JG;Piomelli D;Leff T;Sassone-Corsi P
通讯作者：
Sassone-Corsi P