Cholecystectomy Damages Aging-Associated Intestinal Microbiota Construction.
Cholecystectomy Damages Aging-Associated Intestinal Microbiota Construction.
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胆囊切除术损害与衰老相关的肠道微生物群结构
DOI：
10.3389/fmicb.2018.01402
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发表时间：
2018
影响因子：
5.2
通讯作者：
Geng J
中科院分区：
文献类型：
--
作者：
Wang W;Wang J;Li J;Yan P;Jin Y;Zhang R;Yue W;Guo Q;Geng J
肠道微生物组对维持人体生理平衡和营养代谢至关重要。因胆结石疾病和胆囊炎而进行的腹腔镜胆囊切除术可能会导致肠道微生物群失调，继而引发胆汁酸代谢功能障碍，使患者面临患结直肠癌的高风险。然而，对于胆囊切除术后患者肠道微生物群的特征，我们所知甚少。在此，我们将胆囊切除术患者的微生物组成与健康人群的进行了比较。我们发现，胆囊切除术消除了与衰老相关的粪便共生微生物群，并且进一步确定了几种与胆汁酸代谢相关的细菌，这些细菌通过提高次级胆汁酸水平，促使了结直肠癌的发生。
我们在健康人群中识别出了与衰老相关的粪便微生物群，而这种微生物群在胆囊切除术患者体内缺失。像拟杆菌属这类缺失的肠道细菌与次级胆汁酸呈负相关，可能是胆囊切除术患者患结直肠癌的主要原因。我们的研究为胆囊切除术改变肠道微生物群与结直肠癌之间的关联提供了新的见解，这对结直肠癌的诊断和治疗具有重要价值。
The intestinal microbiome is essential in humans to maintain physiological balance and nutrition metabolism. Laparoscopic cholecystectomy due to gallstone disease and cholecystitis can cause intestinal microbial dysbiosis, and following bile acid metabolism dysfunction, positions the patient at high risk of colorectal cancer. However, little is known regarding intestinal microbiota characteristics in post-cholecystectomy patients. Here, we compared the microbial composition of cholecystectomy patients with that of a healthy population. We determined that cholecystectomy eliminated aging-associated fecal commensal microbiota and further identified several bile acid metabolism-related bacteria as contributors of colorectal cancer incidence via elevation of secondary bile acids. Significance statement We identified aging-associated fecal microbiota in a healthy population, which was lost in cholecystectomy patients. Absent intestinal bacteria, such as Bacteroides, were negatively related to secondary bile acids and may be a leading cause of colorectal cancer incidence in cholecystectomy patients. Our study provides novel insight into the connection between cholecystectomy-altered gut microbiota and colorectal carcinoma, which is of value for colorectal cancer diagnosis and management.
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影响因子：
6.1
作者：
Bernstein, Carol;Holubec, Hana;Bhattacharyya, Achyut K.;Huy Nguyen;Payne, Claire M.;Zaitlin, Beryl;Bernstein, Harris
通讯作者：
Bernstein, Harris
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
10.5
作者：
Brennan CA;Garrett WS
通讯作者：
Garrett WS
人类结直肠癌微生物组的多样化模式
影响因子：
4.2
作者：
Geng J;Fan H;Tang X;Zhai H;Zhang Z
通讯作者：
Zhang Z
DOI：
10.1007/978-3-319-08060-4_11
发表时间：
2014-01-01
期刊：
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
影响因子：
--
作者：
Gerard, J P;Benezery, K;Francois, E
通讯作者：
Francois, E