Impact of partial DAZ1/2 deletion and partial DAZ3/4 deletion on male infertility.
Impact of partial DAZ1/2 deletion and partial DAZ3/4 deletion on male infertility.
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部分 DAZ1/2 缺失和部分 DAZ3/4 缺失对男性不育的影响。
DOI：
10.1016/j.gene.2015.07.083
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发表时间：
2015-10
期刊：
影响因子：
3.5
通讯作者：
Yang X
中科院分区：
文献类型：
--
作者：
Gu K;Li J;Zhang X;Yang X
本研究旨在通过广泛的文献检索，探讨DAZ 1/2部分缺失和DAZ 3/4部分缺失对男性不育的影响。所有与DAZ 1/2和DAZ 3/4部分缺失和男性不育风险相关的病例对照研究均纳入本研究。比值比（OR）和95%置信区间（CI）分别用于评估关联的强度和精确度。纳入了11项部分DAZ 1/2缺失和9项部分DAZ 3/4缺失研究。DAZ 1/2部分缺失与男性不育风险显著相关（OR = 2.58，95%CI：1.60-4.18，I2= 62.1%）。此外，在按种族分层的亚组分析中，在随机效应模型下，部分DAZ 1/2缺失与东亚人群中的男性不育风险显著相关（OR = 2.96，95%CI：1.87-4.71，I2= 51.3%）。同时，在随机效应模型下，分析结果显示部分DAZ 3/4缺失与东亚种族男性不育风险无关（OR = 1.02，95%CI：0.54-1.92，I2= 71.3%），而与非东亚种族男性不育风险无关（OR = 3.56，95%CI：1.13-11.23，I2= 0.0%）。更有趣的是，部分DAZ 1/2缺失与无精子症有关（OR = 2.63，95%CI：1.19-5.81，I2= 64.7%）和少精症（OR = 2.53，95%CI：1.40-4.57，I2= 51.8%），但部分DAZ 3/4缺失与无精子症无关（OR = 0.71，95%CI：0.23-2.22，I2= 71.7%）和少精子症（OR = 1.21，95%CI：0.65-2.24，I2= 55.5%）。在我们的荟萃分析中，部分DAZ 1/2缺失是男性不育的危险因素，不同种族有不同的影响，而部分DAZ 3/4缺失对生育力没有影响，但部分DAZ 3/4缺失可能对非东亚男性有影响。
This study aims to investigate the effect of the partial DAZ1/2 deletion and partial DAZ3/4 deletion on male infertility through a comprehensive literature search. All case–control studies related to partial DAZ1/2 and DAZ3/4 deletions and male infertility risk were included in our study. Odd ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association and its precision, respectively. Eleven partial DAZ1/2 deletion and nine partial DAZ3/4 deletion studies were included. Partial DAZ1/2 deletion was significantly associated with male infertility risk in the overall analysis (ORs = 2.58, 95%CI: 1.60–4.18, I2= 62.1%). Moreover, in the subgroup analysis stratified by ethnicity, partial DAZ1/2 deletion was significantly associated with male infertility risk in the East Asian populations under the random effect model (ORs = 2.96, 95%CI: 1.87–4.71, I2= 51.3%). Meanwhile, the analysis suggested that partial DAZ3/4 deletion was not associated with male infertility risk in East-Asian ethnicity (ORs = 1.02, 95%CI: 0.54–1.92, I2= 71.3%), but not in Non-East Asian under the random effect model (ORs = 3.56, 95%CI: 1.13–11.23, I2= 0.0%,). More interestingly, partial DAZ1/2 deletion was associated with azoospermia (ORs = 2.63, 95%CI: 1.19–5.81, I2= 64.7%) and oligozoospermia (ORs = 2.53, 95%CI: 1.40–4.57, I2= 51.8%), but partial DAZ3/4 deletion was not associated with azoospermia (ORs = 0.71, 95%CI: 0.23–2.22, I2= 71.7%,) and oligozoospermia (ORs = 1.21, 95%CI: 0.65–2.24, I2= 55.5%). In our meta-analysis, partial DAZ1/2 deletion is a risk factor for male infertility and different ethnicities have different influences, whereas partial DAZ3/4 deletion has no effect on fertility but partial DAZ3/4 deletion might have an impact on Non-East Asian male.
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