Trabecular architecture in iliac crest bone biopsies: infra-individual variability in structural parameters and changes with age.
Trabecular architecture in iliac crest bone biopsies: infra-individual variability in structural parameters and changes with age.
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髂嵴骨活检中的小梁结构：结构参数的个体差异以及随年龄的变化。
DOI：
10.1016/8756-3282(88)90012-9
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发表时间：
1988
期刊：
影响因子：
4.1
通讯作者：
Dempster,DW
中科院分区：
文献类型：
--
作者：
Parisien,MV;McMahon,D;Pushparaj,N;Dempster,DW
对27例突然死亡的受试者尸检时获得的双侧髂嵴样本进行了组织形态计量学研究。测量与松质骨结构相关的6个参数：骨体积（BV/TV）、表面密度（BS/TV）、表面/体积比（BS/BV）、骨小梁厚度（Tb. Th.）、骨小梁数目（Tb.N）和骨小梁间隔（Tb.Sp）。右侧和左侧的每个参数的平均值没有显著差异。然而，当个体考虑受试者时，大多数病例的所有参数均存在显著差异。将每例受试者的个体内变异（IIV）计算为两侧平均值的百分比偏差。IIV的范围较宽（0.05-30.27%），每个参数的平均值约为11.5%。在男性中，平均IIV范围为9 - 11%，女性为14 - 16%。BV/TV的IIV与年龄呈正相关。15名男性的子样本产生的数据被用来预测患者组的大小，需要检测最小的显着差异的研究，涉及重复活检。BV/TV的相对增量分别为29%、36%和46%时，需要32、16和8例患者的样本量才具有统计学显著性。Tb.Sp随年龄显著增加，但Tb. Th无显著变化。这支持了这样的观点，即随着年龄的增长，骨丢失主要是通过一种机制发生的，该机制涉及个体小梁板的完全消失。
A histomorphometric study was conducted on bilateral iliac crest samples obtained at autopsy from 27 subjects who had died suddenly. Six parameters related to cancellous bone structure were measured: bone volume (BV/TV), surface density (BS/TV), surface/volume ratio (BS/BV), trabecular thickness (Tb.Th.), trabecular number (Tb.N), and trabecular separation (Tb.Sp). There were no significant differences between right and left sides in the mean values for each parameter. However, when subjects were considered individually, there was a substantial difference in the majority of cases for all parameters. The intra-individual variation (IIV) was calculated for each subject as the percentage deviation from the mean for the two sides. There was a wide range in IIV (0.05–30.27%) with a mean value of approximately 11.5% for each parameter. In males the mean IIV ranged from 9 to 11% and from 14 to 16% in females. The IIV in BV/TV was positively correlated with age. Data generated on a subsample of 15 males were used to predict patient group sizes required to detect minimum significant differences in studies involving repeat biopsies. Sample sizes of 32, 16, and 8 patients would be required for relative increments in BV/TV of 29, 36, and 46%, respectively, to be statistically significant.Tb.Sp increased significantly with age but there was no significant change in Tb.Th. This supports the view that bone loss with aging occurs primarily through a mechanism involving complete disappearance of individual trabecular plates.
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DOI：
--
发表时间：
1941
期刊：
影响因子：
--
作者：
E. Engle
通讯作者：
E. Engle
影响因子：
2
作者：
WHITEHOUSE, WJ
通讯作者：
WHITEHOUSE, WJ
通过新的计算机方法测量平均小梁板厚度。
影响因子：
4.1
作者：
N. Garrahan;R. Mellish;S. Vedi;J. Compston
通讯作者：
J. Compston
髂嵴矿化骨和非矿化骨的定量观察
影响因子：
3.4
作者：
H. A. Ellis;K. Peart
通讯作者：
K. Peart
随着年龄的增长，小梁宽度的减小和小梁间距的增加会导致骨质流失。
影响因子：
4.1
作者：
R. Weinstein;M. Hutson
通讯作者：
M. Hutson