Role of the gut microbiome in cardiovascular drug response: The potential for clinical application.
Role of the gut microbiome in cardiovascular drug response: The potential for clinical application.
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对心血管药物的反应在个体之间差异很大，微生物组在这种变化中的作用越来越受到重视。最近的证据表明，细菌和其他微生物对药物疗效和毒性有直接和间接的影响。药物微生物学旨在揭示由于人体内微生物引起的药物反应的变异性，这些变异性可能通过微生物代谢、微生物代谢物的干扰或宿主酶的修饰来改变药物处置。在这篇综述中，我们提出了最近的进展，我们的理解微生物，宿主代谢和心血管药物之间的相互作用。我们报告了许多心血管药物的证据，或潜在的，肠道微生物相互作用。然而，肠道微生物群对许多心血管药物的影响尚未研究。最后，我们考虑所描述的研究结果的潜在临床应用。
Response to cardiovascular drugs can vary greatly between individuals, and the role of the microbiome in this variability is being increasingly appreciated. Recent evidence indicates that bacteria and other microbes are responsible for direct and indirect effects on drug efficacy and toxicity. Pharmacomicrobiomics aims to uncover variability in drug response due to microbes in the human body, which may alter drug disposition through microbial metabolism, interference by microbial metabolites, or modification of host enzymes. In this review, we present recent advances in our understanding of the interplay between microbes, host metabolism, and cardiovascular drugs. We report numerous cardiovascular drugs with evidence of, or potential for, gut-microbe interactions. However, the effects of gut microbiota on many cardiovascular drugs are yet uninvestigated. Finally, we consider potential clinical applications for the described findings.
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影响因子：
--
作者：
Dawson, Paul A
通讯作者：
Dawson, Paul A
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
5
作者：
D'Argenio, Valeria;Salvatore, Francesco
通讯作者：
Salvatore, Francesco
影响因子：
6.4
作者：
Daniel, Scott G.;Ball, Corbie L.;Hurwitz, Bonnie L.
通讯作者：
Hurwitz, Bonnie L.
影响因子：
2.8
作者：
BETHELL, PH;GOAD, LJ;OTTAWAY, J
通讯作者：
OTTAWAY, J