Cerebral microhaemorrhage in COVID-19: a critical illness related phenomenon?
Cerebral microhaemorrhage in COVID-19: a critical illness related phenomenon?
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DOI：
10.1136/svn-2020-000652
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发表时间：
2020-12
影响因子：
5.9
通讯作者：
Jones B
中科院分区：
文献类型：
--
作者：
Dixon L;McNamara C;Gaur P;Mallon D;Coughlan C;Tona F;Jan W;Wilson M;Jones B
脑微出血越来越多地被认为是COVID-19的并发症。这项观察性回顾性研究旨在通过评估COVID-19和微出血患者的微出血模式和临床特征，进一步研究潜在的病理生理学。通过与其他非COVID-19疾病中类似的微出血模式进行比较，本研究旨在提出可能的共同致病机制。进行了一项回顾性观察性病例系列研究，确定了MRI上所有COVID-19并发脑微出血的患者。使用微出血解剖量表记录微出血的分布和数量，还记录了患者的基线特征和显著性检查结果。发现脑微出血倾向于胼胝体、皮质白色物质和脑干。所有患者都有一个危重病的前期，呼吸衰竭和严重缺氧，需要插管和机械通气。这项研究证明了脑微出血的模式，与非COVID-19相关危重疾病和其他严重缺氧原因患者报告的模式相似。这就提出了一个问题，即微出血是由于SARS-CoV-2感染的直接影响导致的内皮功能障碍，还是由于危重病和缺氧的继发影响。
Cerebral microhaemorrhages are increasingly being recognised as a complication of COVID-19. This observational retrospective study aims to further investigate the potential pathophysiology through assessing the pattern of microhaemorrhage and clinical characteristics of patients with COVID-19 and microhaemorrhage. By comparing with similar patterns of microhaemorrhage in other non-COVID-19 disease, this study aims to propose possible common pathogenic mechanisms. A retrospective observational case series was performed identifying all patients with COVID-19 complicated by cerebral microhaemorrhage on MRI. The distribution and number of microhaemorrhages were recorded using the microbleed anatomical scale, and patients’ baseline characteristics and salient test results were also recorded. Cerebral microhaemorrhages were noted to have a predilection for the corpus callosum, the juxtacortical white matter and brainstem. All patients had a preceding period of critical illness with respiratory failure and severe hypoxia necessitating intubation and mechanical ventilation. This study demonstrates a pattern of cerebral microhaemorrhage that is similar to the pattern reported in patients with non-COVID-19 related critical illness and other causes of severe hypoxia. This raises questions regarding whether microhaemorrhage occurs from endothelial dysfunction due the direct effect of SARS-CoV-2 infection or from the secondary effects of critical illness and hypoxia.
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影响因子：
14.9
作者：
Babicki S;Arndt D;Marcu A;Liang Y;Grant JR;Maciejewski A;Wishart DS
通讯作者：
Wishart DS
DOI：
10.1186/s13195-016-0217-7
发表时间：
2016-11-25
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
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通讯作者：
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影响因子：
9.9
作者：
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通讯作者：
Yoon, BW
影响因子：
24.3
作者：
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通讯作者：
He, Jian-xing
影响因子：
158.5
作者：
Ackermann, Maximilian;Verleden, Stijn E.;Jonigk, Danny
通讯作者：
Jonigk, Danny