Dynamic expression patterns of G protein-regulated inducer of neurite outgrowth 1 (GRIN1) and its colocalization with Galphao implicate significant roles of Galphao-GRIN1 signaling in nervous system.
Dynamic expression patterns of G protein-regulated inducer of neurite outgrowth 1 (GRIN1) and its colocalization with Galphao implicate significant roles of Galphao-GRIN1 signaling in nervous system.
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DOI：
10.1002/dvdy.21686
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发表时间：
2008-09
影响因子：
2.5
通讯作者：
Inoue, Takayoshi
中科院分区：
文献类型：
--
作者：
Masuho, Ikuo;Mototani, Yasumasa;Sahara, Yoshinori;Asami, Junko;Nakamura, Shun;Kozasa, Tohru;Inoue, Takayoshi
GRIN1 (Gprin 1) is a signaling molecule coexpression of which with constitutively active form of Gαo can stimulate neurite extensions in Neuro2a cells, yet its in vivo roles remain elusive. Here we examine expression profiles of GRIN1 during mouse development by in situ hybridization (ISH) and immunohistochemistry. ISH analysis revealed that GRIN1 expression was limited to the nervous system at all developmental stages tested: in the central nervous system, GRIN1 expression occurred within the entire embryonic mantle zones, while it became restricted to sets of nuclei at postnatal to adult stages. Immunohistochemistry using a GRIN1 specific antibody demonstrated that GRIN1 colocalized with Gαo at neuronal dendrites and axons, but it was not detected in glial cells. These results suggest that Gαo-GRIN1 pathway could mediate significant roles in neuronal migration and differentiation at embryonic stages and exert functions in wiring and/or maintenance of specific neural circuitries at postnatal to adult stages.
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通讯作者：
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