Transient Disruption of the Inferior Parietal Lobule Impairs the Ability to Attribute Intention to Action.
Transient Disruption of the Inferior Parietal Lobule Impairs the Ability to Attribute Intention to Action.
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DOI：
10.1016/j.cub.2020.08.104
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发表时间：
2020-12-07
期刊：
影响因子：
--
通讯作者：
Becchio C
中科院分区：
文献类型：
--
作者：
Patri JF;Cavallo A;Pullar K;Soriano M;Valente M;Koul A;Avenanti A;Panzeri S;Becchio C
虽然已经确定额顶叶区域在动作观察中是活跃的，但它们是否在从视觉运动学推断他人意图的能力中发挥因果作用仍然没有确定。在这里报告的实验中，我们结合了离线连续theta-突发刺激（cTBS）与计算建模，以揭示和因果探测顶下小叶（IPL）和额下回（IFG）的单次试验计算。参与者在完成意图辨别任务（辨别观察到的伸手抓握行为的意图）或与意图无关的运动学辨别任务（辨别相同行为的峰值腕部高度）之前，在单独的会话中在左前IPL和左IFG眶部接受cTBS。我们的目标是意图敏感区域，在观察相同的伸手抓握行为时记录的功能磁共振成像活动可以准确区分意图。我们发现，短暂中断活动的左IPL，但不是IFG，削弱了观察员的能力，属性的意图行动。与此相反，与意图无关的运动歧视在很大程度上不受影响。计算分析如何编码-运动运动学的意图的映射-和读出-运动学的意图选择的映射-相交在单次试验水平显示，IPL cTBS并没有降低整体灵敏度的意图读出运动学。相反，它选择性地使意图读出与编码不一致，从而恶化了从信息运动学特征到意图选择的映射。这些结果提供了因果关系的证据，左前IPL如何计算从运动学到意图的映射。Patri等人将联合收割机连续θ脉冲串刺激（cTBS）与计算建模相结合，以因果方式探测额顶叶区域的单次尝试意图计算。他们发现，刺激顶下小叶恶化的映射信息的运动学特征的意图选择在行动观察。
Although it is well established that fronto-parietal regions are active during action observation, whether they play a causal role in the ability to infer others’ intentions from visual kinematics remains undetermined. In experiments reported here, we combined offline continuous theta-burst stimulation (cTBS) with computational modeling to reveal and causally probe single-trial computations in the inferior parietal lobule (IPL) and inferior frontal gyrus (IFG). Participants received cTBS over the left anterior IPL and the left IFG pars orbitalis, in separate sessions, before completing an intention discrimination task (discriminate intention of observed reach-to-grasp acts) or a kinematic discrimination task unrelated to intention (discriminate peak wrist height of the same acts). We targeted intention-sensitive regions whose fMRI activity, recorded when observing the same reach-to-grasp acts, could accurately discriminate intention. We found that transient disruption of activity of the left IPL, but not the IFG, impaired the observer’s ability to attribute intention to action. Kinematic discrimination unrelated to intention, in contrast, was largely unaffected. Computational analyses of how encoding – the mapping of intention to movement kinematics – and readout – the mapping of kinematics to intention choices – intersect at the single-trial level revealed that IPL cTBS did not diminish the overall sensitivity of intention readout to movement kinematics. Rather, it selectively misaligned intention readout with respect to encoding, thereby deteriorating the mapping from informative kinematic features to intention choices. These results provide causal evidence of how left anterior IPL computes the mapping from kinematics to intentions. Patri et al. combine continuous theta-burst stimulation (cTBS) with computational modeling to causally probe single-trial intention computations in fronto-parietal regions. They find that stimulation over the inferior parietal lobule deteriorates the mapping from informative kinematic features to intention choices during action observation.
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DOI：
10.1016/j.cub.2018.02.037
发表时间：
2018-04-02
期刊：
Current biology : CB
影响因子：
--
作者：
Djurdjevic V;Ansuini A;Bertolini D;Macke JH;Zoccolan D
通讯作者：
Zoccolan D
影响因子：
3.7
作者：
Avenanti, Alessio;Paracampo, Riccardo;Aglioti, Salvatore Maria
通讯作者：
Aglioti, Salvatore Maria
影响因子：
3.4
作者：
Bertini, Caterina;Leo, Fabrizio;Ladavas, Elisabetta
通讯作者：
Ladavas, Elisabetta
影响因子：
4.7
作者：
Franca, Michele;Koch, Giacomo;Rothwell, John C.
通讯作者：
Rothwell, John C.
影响因子：
3.7
作者：
Bonini, Luca;Rozzi, Stefano;Fogassi, Leonardo
通讯作者：
Fogassi, Leonardo