Impaired baroreflex function in mice overexpressing alpha-synuclein.
Impaired baroreflex function in mice overexpressing alpha-synuclein.
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DOI：
10.3389/fneur.2013.00103
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发表时间：
2013
影响因子：
3.4
通讯作者：
Roos KP
中科院分区：
文献类型：
--
作者：
Fleming SM;Jordan MC;Mulligan CK;Masliah E;Holden JG;Millard RW;Chesselet MF;Roos KP
Cardiovascular autonomic dysfunction, such as orthostatic hypotension consequent to baroreflex failure and cardiac sympathetic denervation, is frequently observed in the synucleinopathy Parkinson’s disease (PD). In the present study, the baroreceptor reflex was assessed in mice overexpressing human wildtype alpha-synuclein (Thy1-aSyn), a genetic mouse model of synucleinopathy. The beat-to-beat change in heart rate (HR), computed from R–R interval, in relation to blood pressure was measured in anesthetized and conscious mice equipped with arterial blood pressure telemetry transducers during transient bouts of hypertension and hypotension. Compared to wildtype, tachycardia following nitroprusside-induced hypotension was significantly reduced in Thy1-aSyn mice. Thy1-aSyn mice also showed an abnormal cardiovascular response (i.e., diminished tachycardia) to muscarinic blockade with atropine. We conclude that Thy1-aSyn mice have impaired basal and dynamic range of sympathetic and parasympathetic-mediated changes in HR and will be a useful model for long-term study of cardiovascular autonomic dysfunction associated with PD.
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饮食能量摄入可修饰由突变α-突触核蛋白引起的脑干自主神经功能障碍。
影响因子：
4.2
作者：
Griffioen KJ;Rothman SM;Ladenheim B;Wan R;Vranis N;Hutchison E;Okun E;Cadet JL;Mattson MP
通讯作者：
Mattson MP
影响因子：
2.7
作者：
Bissonnette, John M.;Knopp, Sharon J.;Thong, Tran
通讯作者：
Thong, Tran
影响因子：
6.1
作者：
Hallett PJ;McLean JR;Kartunen A;Langston JW;Isacson O
通讯作者：
Isacson O
DOI：
10.1111/j.1460-9568.2008.06346.x
发表时间：
2008-07
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Fleming SM;Tetreault NA;Mulligan CK;Hutson CB;Masliah E;Chesselet MF
通讯作者：
Chesselet MF
影响因子：
6
作者：
Jordan, Maria C.;Henderson, Scott A.;Han, Tieyan;Fishbein, Michael C.;Philipson, Kenneth D.;Roos, Kenneth P.
通讯作者：
Roos, Kenneth P.