Spontaneous HBeAg seroconversion and loss of hepatitis B virus DNA after acute flare due to development of drug resistant mutants during entecavir monotherapy

Spontaneous HBeAg seroconversion and loss of hepatitis B virus DNA after acute flare due to development of drug resistant mutants during entecavir monotherapy
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恩替卡韦单药治疗期间由于耐药突变体的产生导致急性发作后自发性 HBeAg 血清转化和乙型肝炎病毒 DNA 丢失

DOI:
10.1111/j.1872-034x.2008.00411.x
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发表时间:
2009-01
影响因子:
4.2
通讯作者:
Wu, Xiang-Hui
Wu, Xiang-Hui
中科院分区:
医学2区
文献类型:
--
作者:
Mao, Ri-Cheng;Lu, Mengji;Zhang, Ji-Ming;Yin, You-Kuan;Qin, Yan-Li;Weng, Xin-Hua;Wu, Xiang-Hui

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目的:接受恩替卡韦(ETV)治疗的慢性乙型肝炎病毒(HBV)感染患者产生具有病毒反弹的耐药突变体。在这里,我们报告了一个有趣的病例,HBV - DNA自发丢失和血清转化后急性耀斑
Aims: Patients with chronic hepatitis B virus (HBV) infection under entecavir (ETV) treatment develop resistant mutants with viral rebound. Here, we report an interesting case of spontaneous loss of HBV‐DNA and seroconversion following an acute flare aft
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