Sleep problems and their interaction with physical activity and fatigue in hematological cancer patients during onset of high dose chemotherapy.
Sleep problems and their interaction with physical activity and fatigue in hematological cancer patients during onset of high dose chemotherapy.
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DOI：
10.1007/s00520-021-06377-5
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Zimmer P
中科院分区：
文献类型：
--
作者：
Castelli L;Elter T;Wolf F;Watson M;Schenk A;Steindorf K;Bloch W;Hallek M;Joisten N;Zimmer P
血液病患者报告的睡眠问题通常与癌症相关的高水平疲劳有关。尽管人们对实体癌患者睡眠问题的认识正在提高，但对血液肿瘤患者睡眠问题的关注却很少。本研究通过比较血癌患者在化疗开始时的体力活动和疲劳水平来评估睡眠的差异。此外，通过中介分析探讨了睡眠、体力活动和疲劳之间的关系。纳入的样本包括58例新诊断的血液病患者（47.1±15.4岁，51.7%为男性）。受试者在开始治疗后两周内完成睡眠（PSQI）、体力活动（视觉模拟量表）、疲劳（MFI-20）、焦虑、抑郁（HADS）和生活质量（EORTC QLQ-C30）的问卷评估。与德国人口相比，这些样本报告了更多的睡眠问题。睡眠质量好的（约25%）和睡眠质量差的（约75%）受试者的身体活动频率较低(p =。04)，疲劳程度越高(p =。032)，焦虑(p =。003)、抑郁（p = 0.011）和疼痛（p = 0.011）。中介分析显示，睡眠通过身体活动习惯对疲劳有显著的间接影响。这项研究强调了在诱导化疗开始时睡眠问题和身体活动对疲劳的共同作用。这两个参数可以代表有意义的干预目标，以改善患者在化疗期间的状态。该研究已在世卫组织试验注册（DRKS00007824）上注册。
Sleep problems reported by hematological cancer patients are usually linked to higher levels of cancer-related fatigue. Although the awareness of sleep problems in solid cancer patients is rising, there has been less attention to the issue in hematological cancer patients. The present study assesses the differences in sleep by comparing physical activity and fatigue levels among hematological cancer patients during the onset of chemotherapy. Furthermore, it investigates the relationship between sleep, physical activity, and fatigue through mediation analysis. The recruited sample consists of 58 newly diagnosed hematological cancer patients (47.1 ± 15.4 yrs; 51.7% males). Subjects completed questionnaires assessing sleep (PSQI), physical activity (visual analogue scale), fatigue (MFI-20), anxiety, depression (HADS), and quality of life (EORTC QLQ-C30) within two weeks from starting treatment. The sample reported more sleep problems in comparison to the German population norm. The classification as good (ca 25%) or bad sleepers (ca 75%) showed less frequent physical activity (p = .04), higher fatigue (p = .032), anxiety (p = .003), depression (p = .011) and pain (p = .011) in bad sleepers. The mediation analysis revealed significant indirect effects of sleep on fatigue through physical activity habits. This study highlights the combined action of sleep problems and physical activity on fatigue during the onset of induction chemotherapy. These two parameters could represent meaningful intervention targets to improve a patient’s status during chemotherapy. The study was registered on the WHO trial register (DRKS00007824).
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影响因子：
2.7
作者：
Alibhai SM;O'Neill S;Fisher-Schlombs K;Breunis H;Brandwein JM;Timilshina N;Tomlinson GA;Klepin HD;Culos-Reed SN
通讯作者：
Culos-Reed SN
DOI：
10.1007/s00520-017-3655-2
发表时间：
2017-08
期刊：
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
影响因子：
--
作者：
Mark S;Cataldo J;Dhruva A;Paul SM;Chen LM;Hammer MJ;Levine JD;Wright F;Melisko M;Lee K;Conley YP;Miaskowski C
通讯作者：
Miaskowski C
影响因子：
3.1
作者：
Fox, Rina S.;Ancoli-Israel, Sonia;Malcarne, Vanessa L.
通讯作者：
Malcarne, Vanessa L.
影响因子：
2.9
作者：
Bryant, Ashley Leak;Deal, Allison M.;Reeve, Bryce B.
通讯作者：
Reeve, Bryce B.
影响因子：
3.4
作者：
Goswami P;Oliva EN;Ionova T;Else R;Kell J;Fielding AK;Jennings DM;Karakantza M;Al-Ismail S;Collins GP;McConnell S;Langton C;Salek S
通讯作者：
Salek S