Stem cell therapy: a new approach to the treatment of refractory depression.
Stem cell therapy: a new approach to the treatment of refractory depression.
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DOI：
10.1007/s00702-014-1194-2
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发表时间：
2014-10
影响因子：
3.3
通讯作者：
Saito, Toshikazu
中科院分区：
文献类型：
--
作者：
Kigawa, Yoshiyasu;Hashimoto, Eri;Ukai, Wataru;Ishii, Takao;Furuse, Kengo;Tsujino, Hanako;Shirasaka, Tomohiro;Saito, Toshikazu
关键词：
为了更好地了解在早期发展过程中反复暴露于逆境作为难治性抑郁症的危险因素的关系，我们将怀孕的雌性大鼠暴露于乙醇中，并将由此产生的幼鼠暴露于青春期的皮质酮中。然后使用压力强迫游泳测试来诱导抑郁样行为。研究了青春期大鼠脑中抗抑郁药舍曲林和与去端肽胶原复合的神经干细胞（NSC）的组合对不同脑区GABA能中间神经元和突触蛋白密度水平的可能治疗益处。产前和青春期应激的联合暴露导致GABA能中间神经元的小白蛋白（PV）阳性表型减少，前扣带皮层、杏仁核和海马中突触后密度蛋白95（PSD-95）水平降低。舍曲林和神经干细胞治疗逆转了PV阳性细胞和PSD-95水平的下降。此外，舍曲林和神经干细胞的联合治疗导致抑郁样行为减少。这些实验强调了突触重塑和GABA能中间神经元发生在治疗难治性抑郁症中的潜在重要作用，并突出了干细胞和药物联合治疗难治性抑郁症的治疗潜力。
To better understand the relationship of repeated exposure to adversity during early development as a risk factor for refractory depression, we exposed pregnant female rats to ethanol and the resulting pups to corticosterone during adolescence. A stressful forced swim test was then used to induce depression-like behavior. The adolescent rat brains were examined for the possible therapeutic benefit of a combination of sertraline, an antidepressant, and neural stem cells (NSCs) complexed with atelocollagen in relation to the level of GABAergic interneuron and synaptic protein density in different brain regions. The combined exposures of prenatal and adolescent stress resulted in a reduction in parvalbumin (PV)-positive phenotype of GABAergic interneurons and reduced postsynaptic density protein 95 (PSD-95) levels in the anterior cingulate cortex, amygdala, and hippocampus. Treatments with sertraline and NSCs reversed the reductions in PV-positive cells and PSD-95 levels. Furthermore, the combined treatment of sertraline and NSCs resulted in reduced depressive-like behaviors. These experiments underscore a potentially important role for synaptic remodeling and GABAergic interneuron genesis in the treatment of refractory depression and highlight the therapeutic potential of stem cell and pharmacological combination treatments for refractory depression.
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影响因子：
64.8
作者：
Obokata, Haruko;Wakayama, Teruhiko;Vacanti, Charles A.
通讯作者：
Vacanti, Charles A.
影响因子：
3.3
作者：
Miller, MW
通讯作者：
Miller, MW
影响因子：
3.7
作者：
Pozzi L;Pollak Dorocic I;Wang X;Carlén M;Meletis K
通讯作者：
Meletis K
影响因子：
4.7
作者：
Nakazawa, Kazu;Zsiros, Veronika;Jiang, Zhihong;Nakao, Kazuhito;Kolata, Stefan;Zhang, Shuqin;Belforte, Juan E.
通讯作者：
Belforte, Juan E.
DOI：
10.1111/j.1530-0277.1996.tb01762.x
发表时间：
1996-11-01
影响因子：
3.2
作者：
Miller, MW
通讯作者：
Miller, MW