Intracellular trafficking of perforin: to thwart a killer.
Intracellular trafficking of perforin: to thwart a killer.
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DOI:
10.1016/j.immuni.2011.06.008
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发表时间:
2011-06-24
期刊:
影响因子:
32.4
通讯作者:
Metkar S
中科院分区:
文献类型:
--
作者:
Froelich C;Metkar S
How do killer cells restrain perforin, the most potent toxin known to biologists, at its point of synthesis in the endoplasmic reticulum, where conditions are ideal for its activation? In this Issue, Voskoboinik et al. study its trafficking, offering insights into protective mechanisms.
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