Metabolomic Approach to Redox and Nitrosative Reactions in Cardiovascular Diseases.
Metabolomic Approach to Redox and Nitrosative Reactions in Cardiovascular Diseases.
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DOI：
10.3389/fphys.2018.00672
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发表时间：
2018
影响因子：
4
通讯作者：
Mercuro G
中科院分区：
文献类型：
--
作者：
Deidda M;Noto A;Bassareo PP;Cadeddu Dessalvi C;Mercuro G
代谢组学，也被称为代谢组学，是医学领域最新的创新技术之一。它通过检测、鉴定和定量生物样品（如尿液和血液）中的大量代谢物，提供了表型的直接功能读出。代谢物（<1500 Da）代表细胞代谢的输出，说明基因、转录物和蛋白质的表达和活性，并提供对小分子调控的独特见解，可能揭示新的生化模式。代谢组学研究具有将代谢指纹转化为个性化治疗策略的巨大潜力。在相关领域中，心血管疾病（CVD）是最发达的领域之一。然而，心血管疾病仍然是世界范围内死亡的主要原因，在过去六十年中死亡率显着增加。在这种情况下，最近的研究结果表明，氧化还原和亚硝化（RN）反应在心血管疾病的发生和发展中起着重要作用。RN反应通常参与多种细胞和器官功能的稳态调节。相反，这些反应的不平衡可能导致不平衡状态，从而导致心血管疾病。这篇综述的目的是强调代谢组学在研究与CVD相关的RN反应中的作用，为理解可能导致ROS或RNS形成受损的反应机制提供工具。
Metabolomics, also referred to as metabonomics, is one of the most recent innovative technologies in medicine. It offers a direct functional read-out of phenotypes by the detection, identification, and quantification of a large number of metabolites within a biological sample such as urine and blood. Metabolites (<1500 Da) represent the output of cellular metabolism, accounting for expression and activity of genes, transcripts, and proteins, and offering unique insights into small molecule regulation, which may uncover new biochemical patterns. Metabolomics research has considerable potential for translating the metabolic fingerprint into personalized therapeutic strategies. Within the field of interest, cardiovascular disease (CVD) is one of the most developed areas. However, CVD remains the leading cause of death worldwide with a marked increase in mortality rates over the past six decades. In this scenario, recent findings indicate the important role of redox and nitrosative (RN) reactions in CVD development and progression. RN reactions are generally involved in the homeostatic modulation of a wide number of cellular and organ functions. Conversely, the imbalance of these reactions may lead to a condition of allostasis that in turn can cause CVD. The aim of this review is to highlight how the use of metabolomics may be useful for the study of RN reactions related to CVD, providing a tool to understand the mechanisms underlying reactions that could lead to impaired ROS or RNS formation.
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影响因子：
24
作者：
Lewis GD;Ngo D;Hemnes AR;Farrell L;Domos C;Pappagianopoulos PP;Dhakal BP;Souza A;Shi X;Pugh ME;Beloiartsev A;Sinha S;Clish CB;Gerszten RE
通讯作者：
Gerszten RE
DOI：
10.1161/hcg.0000000000000032
发表时间：
2017-04
期刊：
Circulation. Cardiovascular genetics
影响因子：
--
作者：
Cheng S;Shah SH;Corwin EJ;Fiehn O;Fitzgerald RL;Gerszten RE;Illig T;Rhee EP;Srinivas PR;Wang TJ;Jain M;American Heart Association Council on Functional Genomics and Translational Biology; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Stroke Council
通讯作者：
American Heart Association Council on Functional Genomics and Translational Biology; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Stroke Council
影响因子：
3.4
作者：
Dybdahl, B;Wahba, A;Sundan, A
通讯作者：
Sundan, A
影响因子：
15.9
作者：
ISHIBASHI, S;BROWN, MS;HERZ, J
通讯作者：
HERZ, J
影响因子：
2.8
作者：
Mullens, Wilfried;Abrahams, Zuheir;Sokos, George
通讯作者：
Sokos, George