Lactobacillus rhamnosus GG: An Overview to Explore the Rationale of Its Use in Cancer.
Lactobacillus rhamnosus GG: An Overview to Explore the Rationale of Its Use in Cancer.
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DOI：
10.3389/fphar.2017.00603
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发表时间：
2017
影响因子：
5.6
通讯作者：
Libra M
中科院分区：
文献类型：
--
作者：
Banna GL;Torino F;Marletta F;Santagati M;Salemi R;Cannarozzo E;Falzone L;Ferraù F;Libra M
癌症是西方世界第二大死亡原因。在精准医疗时代，大量癌症患者可以通过多种抗癌治疗方案治愈。然而，治疗失败可能是由治疗副作用引起的，例如腹泻，特别是发生在胃肠道或盆腔恶性肿瘤患者中。特别是，腹泻是癌症治疗过程中最常见的胃肠道毒性之一，它几乎可以由目前使用的化疗和放疗策略引起。腹泻对患者的生活质量有严重影响，由于其严重程度，治疗剂量和时间表的调整可能对治疗结果产生负面影响。在这种情况下，益生菌可能在几种涉及炎症性肠道的人类疾病中发挥有趣的作用，其中，鼠李糖乳杆菌GG（LGG）是最具特征和利用的一种。特别是，LGG能够逆转肠道生态失调和中度腹泻。此外，临床前研究已经证明了它在减少与癌症发展相关的慢性炎症方面的作用。本文综述了LGG对癌细胞增殖和肿瘤侵袭的临床前研究结果，以及LGG在癌症患者中用于预防和管理癌症治疗相关腹泻的潜在作用。总体而言，这些令人鼓舞的数据支持进一步研究LGG在接受特定治疗方案（包括化疗和盆腔放疗）的分层患者中的使用，以减少严重腹泻的发生，从而改善治疗依从性和患者的生活质量。
Cancer is the second leading cause of death in the western world. In the era of precision medicine, a significant number of cancer patients can be cured with several anti-cancer therapeutic regimens. However, therapy failure may be caused by treatment side effects, such as diarrhea, especially occurring in patients with gastrointestinal or pelvic malignancies. In particular, diarrhea is one of the most frequent gastrointestinal toxicity during cancer treatment and it can result from nearly bot chemo- and radio-therapeutic strategies currently used. Diarrhea has a serious impact on patients’ quality of life and treatment dosing and schedule modification due to its severity can negatively influence treatment outcomes. In this context, probiotics may play an interesting role in several human diseases with an inflammatory bowel involvement and, among these, Lactobacillus rhamnosus GG (LGG) is one of the most characterized and utilized. In particular, LGG is able to reverse intestinal dysbiosis and moderate diarrhea. Moreover, preclinical studies have documented its effects in reducing chronic inflammation associated with cancer development. This review summarizes the preclinical results of LGG on cancer cells proliferation and tumor invasion as well as the potential role of LGG use in cancer patients for the prevention and management of diarrhea associated with cancer treatment. Overall, these encouraging data support further investigation on the use of LGG in stratified patients undergoing specific therapeutic protocols, including chemotherapy and pelvic radiotherapy, in order to reduce the development of severe diarrhea and thus improve the adherence to the therapy and patients’ quality of life.
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影响因子：
3.7
作者：
Claes IJ;Schoofs G;Regulski K;Courtin P;Chapot-Chartier MP;Rolain T;Hols P;von Ossowski I;Reunanen J;de Vos WM;Palva A;Vanderleyden J;De Keersmaecker SC;Lebeer S
通讯作者：
Lebeer S
影响因子：
7.2
作者：
Arriola E;Wheater M;Lopez MA;Thomas G;Ottensmeier C
通讯作者：
Ottensmeier C
DOI：
10.1080/01635581.2012.700758
发表时间：
2012-01-01
影响因子：
2.9
作者：
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通讯作者：
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影响因子：
7
作者：
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通讯作者：
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影响因子：
45.3
作者：
Benson, AB;Ajani, JA;Wadler, S
通讯作者：
Wadler, S