A Wolbachia factor for male killing in lepidopteran insects.
A Wolbachia factor for male killing in lepidopteran insects.
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DOI：
10.1038/s41467-022-34488-y
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发表时间：
2022-11-14
影响因子：
16.6
通讯作者：
Kiuchi, Takashi
中科院分区：
文献类型：
--
作者：
Katsuma, Susumu;Hirota, Kanako;Matsuda-Imai, Noriko;Fukui, Takahiro;Muro, Tomohiro;Nishino, Kohei;Kosako, Hidetaka;Shoji, Keisuke;Takanashi, Hideki;Fujii, Takeshi;Arimura, Shin-ichi;Kiuchi, Takashi
细菌共生体，如沃尔巴克氏菌，可以操纵其昆虫宿主的性发育和繁殖。例如，沃尔巴克氏体感染通过靶向寄主因子雄性化因子（Masc）诱导亚洲玉米螟雄性特异性死亡，雄性化因子是鳞翅目昆虫雄性化和剂量补偿的必需蛋白。在这里，我们发现了一个沃尔巴克氏体蛋白，命名为Oscar，它通过其锚蛋白重复序列与Masc相互作用。Oscar的胚胎表达抑制masc诱导的雄性化，并导致两种鳞翅目昆虫（O. furnacalis）和家蚕（Bombyx mori）的雄性死亡。我们的研究确定了沃尔巴克氏体诱导雄性杀死宿主后代的机制。细菌共生体，如沃尔巴克氏菌，可以操纵其昆虫宿主的性发育和繁殖。在这里，作者发现了一种沃尔巴克氏体蛋白，它与宿主雄性化因子相互作用，导致鳞翅目昆虫的雄性死亡。
Bacterial symbionts, such as Wolbachia species, can manipulate the sexual development and reproduction of their insect hosts. For example, Wolbachia infection induces male-specific death in the Asian corn borer Ostrinia furnacalis by targeting the host factor Masculinizer (Masc), an essential protein for masculinization and dosage compensation in lepidopteran insects. Here we identify a Wolbachia protein, designated Oscar, which interacts with Masc via its ankyrin repeats. Embryonic expression of Oscar inhibits Masc-induced masculinization and leads to male killing in two lepidopteran insects, O. furnacalis and the silkworm Bombyx mori. Our study identifies a mechanism by which Wolbachia induce male killing of host progeny. Bacterial symbionts, such as Wolbachia species, can manipulate the sexual development and reproduction of their insect hosts. Here, the authors identify a Wolbachia protein that interacts with a host masculinization factor and leads to male killing in lepidopteran insects.
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影响因子：
15.9
作者：
Al-Khodor S;Price CT;Kalia A;Abu Kwaik Y
通讯作者：
Abu Kwaik Y
影响因子：
30.3
作者：
Kaur R;Shropshire JD;Cross KL;Leigh B;Mansueto AJ;Stewart V;Bordenstein SR;Bordenstein SR
通讯作者：
Bordenstein SR
影响因子：
64.8
作者：
Jumper J;Evans R;Pritzel A;Green T;Figurnov M;Ronneberger O;Tunyasuvunakool K;Bates R;Žídek A;Potapenko A;Bridgland A;Meyer C;Kohl SAA;Ballard AJ;Cowie A;Romera-Paredes B;Nikolov S;Jain R;Adler J;Back T;Petersen S;Reiman D;Clancy E;Zielinski M;Steinegger M;Pacholska M;Berghammer T;Bodenstein S;Silver D;Vinyals O;Senior AW;Kavukcuoglu K;Kohli P;Hassabis D
通讯作者：
Hassabis D
影响因子：
1.9
作者：
Ishikawa, Y;Takanashi, T;Huang, YP
通讯作者：
Huang, YP
影响因子：
3.8
作者：
Kageyama, D;Nishimura, G;Ishikawa, Y
通讯作者：
Ishikawa, Y