Living in the endosymbiotic world of Wolbachia: A centennial review.

Living in the endosymbiotic world of Wolbachia: A centennial review.
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DOI:
10.1016/j.chom.2021.03.006
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发表时间:
2021-06-09
影响因子:
30.3
通讯作者:
Bordenstein SR
Bordenstein SR
中科院分区:
医学1区
文献类型:
--
作者:
Kaur R;Shropshire JD;Cross KL;Leigh B;Mansueto AJ;Stewart V;Bordenstein SR;Bordenstein SR

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动物界中最广泛的细胞内细菌是沃尔巴克氏体属的母系遗传内共生菌。它们在全球节肢动物和线虫中的流行以及令人惊叹的寄生和互惠适应性使这些细菌成为共生基础研究的生物原型,并用于遏制人类和农业疾病的应用成果。在这里,我们进行总结性的,在沃尔巴克氏体世界生活百年分析。我们综合文献沃尔巴克氏体的宿主范围,系统发育多样性,基因组学,细胞生物学,并应用于丝虫,虫媒病毒和农业疾病。我们还综述了沃尔巴克氏体的活动组,包括噬菌体WO和它的重要性,在节肢动物的标志表型。最后,沃尔巴克氏体系统是利用生物多样性、生物技术和生物信息学课程进行基于发现的科学教育的典范。当我们接近沃尔巴克氏体研究的世纪时,这种共生的跨学科科学成为巩固和教授内共生生命的综合规则的模型。沃尔巴克氏体是动物体内分布最广的内共生体,发现于近世纪前。在这里,Kaur等人回顾了沃尔巴克氏体研究为生物学提供的各种教训和应用,从宿主向性和共同进化,基因组学和遗传移动的元素,到它们在人类健康和社会中的转化潜力。
The most widespread intracellular bacteria in the animal kingdom are maternally-inherited endosymbionts of the genus Wolbachia. Their prevalence in arthropods and nematodes worldwide and stunning arsenal of parasitic and mutualistic adaptations make these bacteria a biological archetype for basic studies of symbiosis and applied outcomes for curbing human and agricultural diseases. Here, we conduct a summative, centennial analysis of living in the Wolbachia world. We synthesize literature on Wolbachia’s host range, phylogenetic diversity, genomics, cell biology, and applications to filarial, arboviral, and agricultural diseases. We also review the mobilome of Wolbachia including phage WO and its essentiality to hallmark phenotypes in arthropods. Finally, the Wolbachia system is an exemplar for discovery-based science education using biodiversity, biotechnology, and bioinformatics lessons. As we approach a century of Wolbachia research, the interdisciplinary science of this symbiosis stands as a model for consolidating and teaching the integrative rules of endosymbiotic life. Wolbachia, the most widespread endosymbiont in animals, was discovered nearly a century ago. Here, Kaur et al. review the various lessons and applications Wolbachia studies offer for biology, from host tropism and co-evolution, genomics and genetic mobile elements, to their translational potential in human health and society.
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