Sustained reduction in prevalence of lymphatic filariasis infection in spite of missed rounds of mass drug administration in an area under mosquito nets for malaria control.
Sustained reduction in prevalence of lymphatic filariasis infection in spite of missed rounds of mass drug administration in an area under mosquito nets for malaria control.
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DOI：
10.1186/1756-3305-4-90
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发表时间：
2011-05-25
影响因子：
3.2
通讯作者：
Molyneux DH
中科院分区：
文献类型：
--
作者：
Njenga SM;Mwandawiro CS;Wamae CN;Mukoko DA;Omar AA;Shimada M;Bockarie MJ;Molyneux DH
消除淋巴丝虫病全球方案(GPELF)由世界卫生组织(WHO)于2000年设立，目标是到2020年在全球消除淋巴丝虫病(LF)这一公共卫生问题。抗丝虫病药物的大规模给药(MDA)是建议全球消除的主要战略。肯尼亚于2002年在沿海地区启动了消除淋巴丝虫病国家方案。同年，在马林迪区一个高度流行的地区启动了一项纵向研究项目，以监测丙型肝炎期间低频感染的趋势。沿海地区驱虫蚊帐的高覆盖率与疟疾住院人数的急剧下降有关；驱虫蚊帐的大量使用预计也会对同样由蚊子传播的低频感染产生影响。在为期8年的时间里，对8个研究村庄进行了4轮丙二醛与柠檬酸二乙酯(DEC)和阿苯达唑的治疗。虽然每年都没有使用丙二醛，但微丝虫病的总患病率从2002年的20.9%显着下降到2009年的0.9%。同样，丝虫抗原血症的患病率从2002年的34.6%下降到2009年的10.8%。2009年，自该方案开始以来出生的所有接受检查的儿童丝虫抗原均为阴性。尽管研究村庄在某些年份错过了丙二醛，但在每一次调查中都观察到感染流行率和感染强度显著降低。更重要的是，在两轮治疗之间，感染流行率没有反弹。然而，由于混杂的变量，如驱虫蚊帐，很难将减少归因于丙二醛，因为驱虫蚊帐可以显著减少丝虫病媒介的暴露。结果表明，应鼓励国家消除低频气体方案继续提供丙二醛，尽管存在可能导致某些年份缺少丙二醛的制约因素。
The Global Programme to Eliminate Lymphatic Filariasis (GPELF) was established by the World Health Organisation (WHO) in 2000 with the goal of eliminating lymphatic filariasis (LF) as a public health problem globally by 2020. Mass drug administration (MDA) of antifilarial drugs is the principal strategy recommended for global elimination. Kenya launched a National Programme for Elimination of Lymphatic Filariasis (NPELF) in Coast Region in 2002. During the same year a longitudinal research project to monitor trends of LF infection during MDA started in a highly endemic area in Malindi District. High coverage of insecticide treated nets (ITNs) in the coastal region has been associated with dramatic decline in hospital admissions due to malaria; high usage of ITNs is also expected to have an impact on LF infection, also transmitted by mosquitoes. Four rounds of MDA with diethylcarbamazine citrate (DEC) and albendazole were given to 8 study villages over an 8-year period. Although annual MDA was not administered for several years the overall prevalence of microfilariae declined significantly from 20.9% in 2002 to 0.9% in 2009. Similarly, the prevalence of filarial antigenaemia declined from 34.6% in 2002 to 10.8% in 2009. All the examined children born since the start of the programme were negative for filarial antigen in 2009. Despite the fact that the study villages missed MDA in some of the years, significant reductions in infection prevalence and intensity were observed at each survey. More importantly, there were no rebounds in infection prevalence between treatment rounds. However, because of confounding variables such as insecticide-treated bed nets (ITNs), it is difficult to attribute the reduction to MDA alone as ITNs can lead to a significant reduction in exposure to filariasis vectors. The results indicate that national LF elimination programmes should be encouraged to continue provision of MDA albeit constraints that may lead to missing of MDA in some years.
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DOI：
10.1016/j.trstmh.2008.04.039
发表时间：
2008-10-01
影响因子：
2.2
作者：
Njenga, S. M.;Wamae, C. N.;Molyneux, D. H.
通讯作者：
Molyneux, D. H.
DOI：
10.1186/1475-2883-3-9
发表时间：
2004-09-03
期刊：
Filaria journal
影响因子：
--
作者：
Lammie, Patrick J;Weil, Gary;Ottesen, Eric
通讯作者：
Ottesen, Eric
影响因子：
3.8
作者：
Boyd, Alexis;Won, Kimberly Y.;Lammie, Patrick J.
通讯作者：
Lammie, Patrick J.
DOI：
10.1016/s0035-9203(02)90080-5
发表时间：
2002-04-01
影响因子：
2.2
作者：
Ramzy, Reda M R
通讯作者：
Ramzy, Reda M R
影响因子：
--
作者：
Njenga, S. M.;Wamae, C. N.;Molyneux, D. H.
通讯作者：
Molyneux, D. H.