A novel class of polymeric pH-responsive MRI CEST agents.
A novel class of polymeric pH-responsive MRI CEST agents.
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DOI:
10.1039/c3cc42452a
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发表时间:
2013-07-21
期刊:
影响因子:
--
通讯作者:
Gao J
中科院分区:
文献类型:
--
作者:
Zhang S;Zhou K;Huang G;Takahashi M;Sherry AD;Gao J
In this communication, we report that ionizable, tertiary amine-based block copolymers can be used as pH-responsive contrast agents for magnetic resonance imaging (MRI) through the chemical exchange saturation transfer (CEST) mechanism. The CEST signal is essentially “off” when the polymers form micelles near physiological pH but is activated to the “on” state when the micelle dissociates in an acidic environment.
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