A novel class of polymeric pH-responsive MRI CEST agents.

A novel class of polymeric pH-responsive MRI CEST agents.
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DOI:
10.1039/c3cc42452a
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发表时间:
2013-07-21
期刊:
Chemical communications (Cambridge, England)
影响因子:
--
通讯作者:
Gao J
Gao J
中科院分区:
其他
文献类型:
--
作者:
Zhang S;Zhou K;Huang G;Takahashi M;Sherry AD;Gao J

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在这篇通讯中,我们报道了可电离的叔胺基嵌段共聚物可以通过化学交换饱和转移(CEST)机制用作磁共振成像(MRI)的pH响应对比剂。当聚合物在生理pH附近形成胶束时,CEST信号基本上是“关”的,但当胶束在酸性环境中解离时,CEST信号被激活到“开”状态。
In this communication, we report that ionizable, tertiary amine-based block copolymers can be used as pH-responsive contrast agents for magnetic resonance imaging (MRI) through the chemical exchange saturation transfer (CEST) mechanism. The CEST signal is essentially “off” when the polymers form micelles near physiological pH but is activated to the “on” state when the micelle dissociates in an acidic environment.
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