Unconventional Protein Secretion in Brain Tumors Biology: Enlightening the Mechanisms for Tumor Survival and Progression.
Unconventional Protein Secretion in Brain Tumors Biology: Enlightening the Mechanisms for Tumor Survival and Progression.
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DOI：
10.3389/fcell.2022.907423
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发表时间：
2022
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
非典型分泌途径，统称为非常规蛋白质分泌（UPS），是通常与应激诱导条件相关的替代分泌机制。UPS允许缺乏信号肽的蛋白质被分泌，避免了传统的内质网-高尔基复合体分泌途径。通常依赖于经典途径分泌的分子也可以使用高尔基体旁路（非常规途径之一）到达细胞外空间。UPS研究在文献中越来越多，包括其在几种疾病的生物学中的意义。脑肿瘤细胞和肿瘤微环境之间的细胞间通讯由各种分子协调，包括调节肿瘤生长、增殖和侵袭的经典和非经典分泌蛋白。成人脑肿瘤，如神经胶质瘤，是一种侵袭性和致命的癌症，预后不良，可以利用UPS机制与其微环境进行交流。在这里，我们提供了功能的UPS机制的背景下，肿瘤生物学的见解，特别关注分泌的蛋白质通过替代途径作为关键的监管机构在维持脑肿瘤。
Non-canonical secretion pathways, collectively known as unconventional protein secretion (UPS), are alternative secretory mechanisms usually associated with stress-inducing conditions. UPS allows proteins that lack a signal peptide to be secreted, avoiding the conventional endoplasmic reticulum-Golgi complex secretory pathway. Molecules that generally rely on the canonical pathway to be secreted may also use the Golgi bypass, one of the unconventional routes, to reach the extracellular space. UPS studies have been increasingly growing in the literature, including its implication in the biology of several diseases. Intercellular communication between brain tumor cells and the tumor microenvironment is orchestrated by various molecules, including canonical and non-canonical secreted proteins that modulate tumor growth, proliferation, and invasion. Adult brain tumors such as gliomas, which are aggressive and fatal cancers with a dismal prognosis, could exploit UPS mechanisms to communicate with their microenvironment. Herein, we provide functional insights into the UPS machinery in the context of tumor biology, with a particular focus on the secreted proteins by alternative routes as key regulators in the maintenance of brain tumors.
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DOI：
10.1083/jcb.201106098
发表时间：
2011-12-12
期刊：
The Journal of cell biology
影响因子：
--
作者：
Bruns C;McCaffery JM;Curwin AJ;Duran JM;Malhotra V
通讯作者：
Malhotra V
影响因子：
3.6
作者：
Hamed HA;Yacoub A;Park MA;Eulitt P;Sarkar D;Dimitrie IP;Chen CS;Grant S;Curiel DT;Fisher PB;Dent P
通讯作者：
Dent P
DOI：
10.1073/pnas.0914072107
发表时间：
2010-08-31
影响因子：
11.1
作者：
Auf, Gregor;Jabouille, Arnaud;Moenner, Michel
通讯作者：
Moenner, Michel
影响因子：
--
作者：
Akl MR;Nagpal P;Ayoub NM;Tai B;Prabhu SA;Capac CM;Gliksman M;Goy A;Suh KS
通讯作者：
Suh KS
影响因子：
5
作者：
Cataltepe, O.;Arikan, M. C.;Cataltepe, S.
通讯作者：
Cataltepe, S.