Metabolic syndrome and concomitant diabetes mellitus are associated with higher risk of cardiovascular comorbidity in patients with primary glomerular diseases: A retrospective observational study.
Metabolic syndrome and concomitant diabetes mellitus are associated with higher risk of cardiovascular comorbidity in patients with primary glomerular diseases: A retrospective observational study.
复制标题
代谢综合征和合并糖尿病与原发性肾小球疾病患者心血管合并症的较高风险相关：一项回顾性观察研究
DOI：
10.1002/clc.23388
复制
发表时间：
2020-09
影响因子：
2.7
通讯作者：
Liang X
中科院分区：
文献类型：
--
作者：
Xie Z;Li Z;Dong W;Chen Y;Li R;Wu Y;Lin T;Tao Y;Liang H;Wang W;Liu S;Ye Z;Shi W;Liang X
代谢综合征（MS）和糖尿病（DM）是普通人群心血管疾病的危险因素。然而，研究其对原发性肾小球疾病（PGD）影响的研究很少。MS和合并DM与PGD中心血管合并症的风险较高相关。在一项回顾性观察设计中，我们分析了3622例住院成人PGD患者，并比较了非MS、MS伴和不伴DM的心血管合并症的患病率。采用单变量和多变量logistic回归分析确定心血管并发症的危险因素。在3622例PGD患者中，308例（8.5%）合并MS，其中180例（5.0%）合并DM，128例（3.5%）未合并DM。164例（4.5%）合并心血管并发症。根据估计的肾小球滤过率和病理类型分层，MS合并DM患者的心血管合并症患病率高于无MS患者。Logistic回归分析显示MS和合并DM（OR：2.496，95% CI：1.600 - 3.894，P < .001），年龄较大（OR：1.060，95% CI：1.047 - 1.074，P < .001），男性（OR：1.536，95% CI：1.072 - 2.200，P = 0.019），血清总胆红素水平升高（OR：1.002，95% CI：1.001 - 1.003，P < .001），高尿酸血症（OR：1.901，95% CI：1.327 - 2.725，P < .001），特发性膜性肾病（OR：2.874，95% CI：1.244 - 6.640，P < .001）和局灶节段性肾小球硬化（OR：2.906，95% CI：1.147 - 7.358，P < .001）与心血管合并症的风险较高独立相关。在PGD患者中，MS和合并DM与心血管合并症风险增加相关。MS/DM和心血管结局之间的因果关系需要更多的证据来澄清。
Metabolic syndrome (MS) and diabetes mellitus (DM) are risk factors for cardiovascular diseases in general population. However, there was a paucity of studies investigating their impact in primary glomerular diseases (PGD). MS and concomitant DM are associated with higher risk of cardiovascular comorbidity in PGD. In a retrospective observational design, we analyzed 3622 hospitalized adult PGD patients and compared the prevalence of cardiovascular comorbidity in non‐MS, MS with and without DM. Risk factors for cardiovascular comorbidity were identified using univariate and multivariate logistic regression. Among 3622 PGD patients, 308 (8.5%) cases accompanied with MS, including 180 (5.0%) patients with DM and 128 (3.5%) without DM. One hundred and sixty four (4.5%) cases coexisted with cardiovascular comorbidity. Patients with MS and concomitant DM exhibited a higher prevalence of cardiovascular comorbidity than those without MS stratified by estimated glomerular filtration rate and pathological types. Logistic regression showed that MS and concomitant DM (OR: 2.496, 95% CI: 1.600‐3.894, P < .001), older age (OR: 1.060, 95% CI: 1.047‐1.074, P < .001), male (OR: 1.536, 95% CI: 1.072‐2.200, P = .019), higher level of serum ti (OR: 1.002, 95% CI: 1.001‐1.003, P < .001), hyperuricemia (OR: 1.901, 95% CI: 1.327‐2.725, P < .001), idiopathic membranous nephropathy (OR: 2.874, 95% CI: 1.244‐6.640, P < .001) and focal segmental glomerulosclerosis (OR: 2.906, 95% CI: 1.147‐7.358, P < .001) were independently associated with a higher risk for cardiovascular comorbidity. In PGD patients, MS and concomitant DM are associated with an increased risk for cardiovascular comorbidity. More evidence for the causal link between MS/DM and cardiovascular outcomes is needed to be clarified.
登录
查看更多内容
影响因子：
168.9
作者：
Matsushita, Kunihiro;van der Velde, Marije;Astor, Brad C.;Woodward, Mark;Levey, Andrew S.;de Jong, Paul E.;Coresh, Josef;Gansevoort, Ron T.
通讯作者：
Gansevoort, Ron T.
影响因子：
13.2
作者：
Lucove, Jaime;Vupputuri, Suma;Russell, Marie
通讯作者：
Russell, Marie
影响因子：
168.9
作者：
Jha, Vivekanand;Garcia-Garcia, Guillermo;Yang, Chih-Wei
通讯作者：
Yang, Chih-Wei
DOI：
10.1097/01.asn.0000103870.31606.90
发表时间：
2004-01-01
影响因子：
13.6
作者：
Ravani, P;Brunori, G;Malberti, F
通讯作者：
Malberti, F
DOI：
10.1016/s0140-6736(17)32152-9
发表时间：
2017-09-16
期刊：
Lancet (London, England)
影响因子：
--
作者：
GBD 2016 Causes of Death Collaborators
通讯作者：
GBD 2016 Causes of Death Collaborators