Non-coding RNAs: the "dark matter" of cardiovascular pathophysiology.
Non-coding RNAs: the "dark matter" of cardiovascular pathophysiology.
复制标题
DOI：
10.3390/ijms141019987
复制
发表时间：
2013-10-09
影响因子：
5.6
通讯作者：
Indolfi C
中科院分区：
文献类型：
--
作者：
Iaconetti C;Gareri C;Polimeni A;Indolfi C
对哺乳动物转录组的大规模分析已经确定了大量不翻译成蛋白质的不同RNA分子。事实上，使用新的测序技术已经确定，大部分基因组被转录，产生不编码蛋白质的RNA（ncRNA）的异质群体。新出现的数据表明，这些转录影响心血管疾病的发展。最具特征的非编码RNA家族由短的高度保守的RNA分子代表，称为microRNA（miRNA），其通过转录物降解或翻译抑制介导mRNA沉默的过程。这些microRNA（miRNAs）在心血管组织中表达，并在许多心血管病理学中发挥关键作用，例如冠状动脉疾病（CAD）和心力衰竭（HF）。其他ncRNA（如长链非编码RNA）与心血管疾病之间的潜在联系很有趣，但这些转录物的功能在很大程度上是未知的。因此，ncRNA的功能表征对于提高对心血管疾病所涉及的细胞过程的整体理解以定义新的治疗策略是必不可少的。本文综述了目前不同的ncRNA类的知识，并总结了他们在心血管疾病的发展和作用。
Large-scale analyses of mammalian transcriptomes have identified a significant number of different RNA molecules that are not translated into protein. In fact, the use of new sequencing technologies has identified that most of the genome is transcribed, producing a heterogeneous population of RNAs which do not encode for proteins (ncRNAs). Emerging data suggest that these transcripts influence the development of cardiovascular disease. The best characterized non-coding RNA family is represented by short highly conserved RNA molecules, termed microRNAs (miRNAs), which mediate a process of mRNA silencing through transcript degradation or translational repression. These microRNAs (miRNAs) are expressed in cardiovascular tissues and play key roles in many cardiovascular pathologies, such as coronary artery disease (CAD) and heart failure (HF). Potential links between other ncRNAs, like long non-coding RNA, and cardiovascular disease are intriguing but the functions of these transcripts are largely unknown. Thus, the functional characterization of ncRNAs is essential to improve the overall understanding of cellular processes involved in cardiovascular diseases in order to define new therapeutic strategies. This review outlines the current knowledge of the different ncRNA classes and summarizes their role in cardiovascular development and disease.
登录
查看更多内容
影响因子：
14.9
作者：
Chen C;Ridzon DA;Broomer AJ;Zhou Z;Lee DH;Nguyen JT;Barbisin M;Xu NL;Mahuvakar VR;Andersen MR;Lao KQ;Livak KJ;Guegler KJ
通讯作者：
Guegler KJ
影响因子：
64.8
作者：
Cordes KR;Sheehy NT;White MP;Berry EC;Morton SU;Muth AN;Lee TH;Miano JM;Ivey KN;Srivastava D
通讯作者：
Srivastava D
影响因子：
30.8
作者：
Bentwich, I;Avniel, A;Bentwich, Z
通讯作者：
Bentwich, Z
影响因子：
4.6
作者：
Deacon, Dekker C.;Nevis, Kathleen R.;Burns, Caroline E.
通讯作者：
Burns, Caroline E.
影响因子：
4.8
作者：
Davis, Brandi N.;Hilyard, Aaron C.;Hata, Akiko
通讯作者：
Hata, Akiko