Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy.

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy.
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DOI:
10.1002/mds.27115
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发表时间:
2017-09
期刊:
Movement disorders : official journal of the Movement Disorder Society
影响因子:
--
通讯作者:
Stoessl AJ
Stoessl AJ
中科院分区:
其他
文献类型:
--
作者:
Obeso JA;Stamelou M;Goetz CG;Poewe W;Lang AE;Weintraub D;Burn D;Halliday GM;Bezard E;Przedborski S;Lehericy S;Brooks DJ;Rothwell JC;Hallett M;DeLong MR;Marras C;Tanner CM;Ross GW;Langston JW;Klein C;Bonifati V;Jankovic J;Lozano AM;Deuschl G;Bergman H;Tolosa E;Rodriguez-Violante M;Fahn S;Postuma RB;Berg D;Marek K;Standaert DG;Surmeier DJ;Olanow CW;Kordower JH;Calabresi P;Schapira AHV;Stoessl AJ

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This article reviews and summarizes 200 years of Parkinson’s disease. It comprises a relevant history of Dr. James Parkinson’s himself and what he described accurately and what he missed from today’s perspective. Parkinson’s disease today is understood as a multietiological condition with uncertain etiopathogenesis. Many advances have occurred regarding pathophysiology and symptomatic treatments, but critically important issues are still pending resolution. Among the latter, the need to modify disease progression is undoubtedly a priority. In sum, this multiple-author article, prepared to commemorate the bicentenary of the shaking palsy, provides a historical state-of-the-art account of what has been achieved, the current situation, and how to progress toward resolving Parkinson’s disease.
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