Loss of DUSP4 Expression as a Prognostic Biomarker in Clear Cell Renal Cell Carcinoma.
Loss of DUSP4 Expression as a Prognostic Biomarker in Clear Cell Renal Cell Carcinoma.
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肾透明细胞癌中作为预后生物标志物的DUSP4表达缺失。
DOI：
10.3390/diagnostics11101939
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发表时间：
2021-10-19
期刊：
影响因子：
--
通讯作者：
Paik SS
中科院分区：
文献类型：
--
作者：
Bang S;Jee S;Son H;Wi YC;Kim H;Park H;Myung J;Shin SJ;Paik SS
双特异性蛋白磷酸酶4（DUSP 4）是丝裂原活化蛋白激酶的负调节因子。DUSP 4在肾细胞癌中的表达对预后的影响还没有得到很好的研究。因此，我们通过免疫组化（IHC）评估了DUSP 4在肾透明细胞癌中表达的临床病理意义。通过生存分析评估根据DUSP 4表达的临床结果，并通过在线分析（Kaplan-Meier法）证实mRNA表达与预后之间的关联。在大多数组织学亚型的肾细胞癌中发现DUSP 4表达缺失。肾透明细胞癌中DUSP 4表达的缺失与年龄（p = 0.033）、高组织学分级（p < 0.001）、肿瘤坏死（p <0.001）和高pT类别（p < 0.001）显著相关。在生存分析中，DUSP 4表达的缺失与癌症特异性生存和无复发生存的不良临床结局相关（分别为p = 0.010和p = 0.007）。TCGA数据分析显示，DUSP 4 mRNA表达低的患者总体生存期较短（p = 0.023）。这些结果表明，DUSP 4表达的缺失可用作预测肾透明细胞癌患者临床结局的潜在生物标志物。
Dual-specificity protein phosphatase 4 (DUSP4) is a negative regulator of mitogen-activated protein kinases. The prognostic impact of DUSP4 expression in renal cell carcinoma is not well studied. Therefore, we evaluated the clinicopathological implications of DUSP4 expression in clear cell renal cell carcinoma by performing immunohistochemistry (IHC). The clinical outcome according to DUSP4 expression was evaluated through survival analyses, and the association between mRNA expression and prognosis was confirmed by online analysis (Kaplan–Meier plotter). Loss of DUSP4 expression was noted in most histological subtypes of renal cell carcinoma. Loss of DUSP4 expression in clear cell renal cell carcinoma was significantly correlated with old age (p = 0.033), high histologic grade (p < 0.001), tumor necrosis (p < 0.001), and high pT category (p < 0.001). In survival analysis, loss of DUSP4 expression was associated with poor clinical outcomes in cancer-specific survival and recurrence-free survival (p = 0.010 and p = 0.007, respectively). Upon TCGA data analysis, patients with low DUSP4 mRNA expression showed a shorter overall survival (p = 0.023). These results suggest that loss of DUSP4 expression can be used as a potential biomarker for predicting clinical outcomes in clear cell renal cell carcinoma patients.
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影响因子：
2.4
作者：
Kim H;Jang SM;Ahn H;Sim J;Yi K;Chung Y;Han H;Rehman A;Chung MS;Jang K;Paik SS
通讯作者：
Paik SS
影响因子：
5.7
作者：
Ichimanda M;Hijiya N;Tsukamoto Y;Uchida T;Nakada C;Akagi T;Etoh T;Iha H;Inomata M;Takekawa M;Moriyama M
通讯作者：
Moriyama M
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
7.5
作者：
Lin, Hua;Qiu, Shiyang;Sun, Shenghua
通讯作者：
Sun, Shenghua
DOI：
10.1007/978-94-007-7359-2_11
发表时间：
2014-01-01
期刊：
CARBONIC ANHYDRASE: MECHANISM, REGULATION, LINKS TO DISEASE, AND INDUSTRIAL APPLICATIONS
影响因子：
--
作者：
Benej, Martin;Pastorekova, Silvia;Pastorek, Jaromir
通讯作者：
Pastorek, Jaromir