Clinicopathological significance of dual-specificity protein phosphatase 4 expression in invasive ductal carcinoma of the breast.
Clinicopathological significance of dual-specificity protein phosphatase 4 expression in invasive ductal carcinoma of the breast.
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DOI：
10.4048/jbc.2015.18.1.1
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发表时间：
2015-03
影响因子：
2.4
通讯作者：
Paik SS
中科院分区：
文献类型：
--
作者：
Kim H;Jang SM;Ahn H;Sim J;Yi K;Chung Y;Han H;Rehman A;Chung MS;Jang K;Paik SS
双特异性蛋白磷酸酶4（DUSP 4），也称为丝裂原活化蛋白激酶磷酸酶（MKP）2，是诱导型核MKP组的成员。DUSP 4在癌症发展和进展中的作用似乎随恶性肿瘤的类型而变化。本研究的目的是调查DUSP 4在乳腺浸润性导管癌的病例系列中的表达。我们分别构建了16、14、47和266例正常乳腺组织、普通导管增生、导管原位癌和浸润性导管癌的组织芯片。免疫组化法检测DUSP 4的表达。观察到细胞质DUSP 4表达。DUSP 4在恶性病例中的表达频率高于良性病例（p=0.024）。恶性肿瘤的平均DUSP 4表达评分显著高于良性病变（p=0.019）。DUSP 4表达与较大的肿瘤大小（> 2cm，p=0.015）显著相关。在所有266例患者中，总生存期或无病生存期与DUSP 4表达之间无显著相关性。我们评估了DUSP 4表达对120例T1期肿瘤患者生存期的影响。有趣的是，Kaplan-Meier生存曲线显示，DUSP 4表达对患者总生存期（p=0.034，对数秩检验）和无病生存期（p=0.045，对数秩检验）均有显著影响。在早期T期乳腺癌中，DUSP 4表达与预后不良相关。DUSP 4在乳腺恶性肿瘤中经常上调，并且可能在癌症的发展和进展中起重要作用。此外，它可能是不良预后的标志物，特别是在早期T1期癌症患者中。
Dual-specificity protein phosphatase 4 (DUSP4), also known as mitogen-activated protein kinase phosphatase (MKP) 2 is a member of the inducible nuclear MKP group. The role of DUSP4 in cancer development and progression appears to vary with the type of malignancy. The purpose of this study was to investigate DUSP4 expression in a case series of invasive ductal carcinoma of the breast. We constructed tissue microarrays consisting of 16, 14, 47, and 266 cases of normal breast tissue, usual ductal hyperplasia, ductal carcinoma in situ, and invasive ductal carcinoma, respectively. DUSP4 expression was investigated by immunohistochemistry. Cytoplasmic DUSP4 expression was observed. DUSP4 was more frequently expressed in malignant than in benign cases (p=0.024). The mean DUSP4 expression score was significantly higher in malignant tumors than in benign lesions (p=0.019). DUSP4 expression was significantly correlated with a larger tumor size (>2 cm, p=0.015). There was no significant correlation between overall survival or disease-free survival and DUSP4 expression in all 266 patients. We evaluated the impact of DUSP4 expression on the survival of 120 patients with T1-stage tumors. Interestingly, Kaplan-Meier survival curves revealed that DUSP4 expression had a significant effect on both overall patient survival (p=0.034, log-rank test) and disease-free survival (p=0.045, log-rank test). In early T-stage breast cancer, DUSP4 expression was associated with a worse prognosis. DUSP4 is frequently upregulated in breast malignancy, and may play an important role in cancer development and progression. In addition, it may be a marker of adverse prognosis, especially in patients with early T1-stage cancer.
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影响因子：
3.4
作者：
Jang, Se Min;Sim, Jongmin;Paik, Seung Sam
通讯作者：
Paik, Seung Sam
影响因子：
11.2
作者：
Waha, Anke;Felsberg, Joerg;Waha, Andreas
通讯作者：
Waha, Andreas
影响因子：
3.8
作者：
Baglia, Michelle L.;Cai, Qiuyin;Zheng, Ying;Wu, Jie;Su, Yinghao;Ye, Fei;Bao, Ping-Ping;Cai, Hui;Zhao, Zhiguo;Balko, Justin;Zheng, Wei;Lu, Wei;Shu, Xiao-Ou
通讯作者：
Shu, Xiao-Ou
DOI：
10.1006/bbrc.2001.4243
发表时间：
2001-02-02
影响因子：
3.1
作者：
Yip-Schneider, MT;Lin, A;Marshall, MS
通讯作者：
Marshall, MS
影响因子：
8
作者：
Armes, JE;Hammet, F;Venter, DJ
通讯作者：
Venter, DJ