Oral Clefts and Academic Performance in Adolescence: The Impact of Anesthesia-Related Neurotoxicity, Timing of Surgery, and Type of Oral Clefts.
Oral Clefts and Academic Performance in Adolescence: The Impact of Anesthesia-Related Neurotoxicity, Timing of Surgery, and Type of Oral Clefts.
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DOI：
10.1597/15-185
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发表时间：
2017-07
期刊：
影响因子：
--
通讯作者：
Hansen TG
中科院分区：
文献类型：
--
作者：
Clausen NG;Pedersen DA;Pedersen JK;Møller SE;Grosen D;Wehby GL;Christensen K;Hansen TG
Early life exposure to anesthesia and surgery is suspected to associate with cognitive impairment later in life. We compared academic achievement among adolescents with cleft lip only (CL), cleft palate only (CP) and cleft lip and cleft palate (CLP) with a non-cleft control group to investigate, whether outcome depends on timing and number of operations during childhood and/or type of oral cleft. Nation-wide, register-based follow-up study. Danish birth cohort 1986–1990 558 children with isolated CL (n=171), CLP (n=222) or CP (n=195), of which 509 children had been exposed to anesthesia and one or more cleft operation(s), and a 5% sample of the birth cohort (n=14,677). Test-score in the Danish standardized 9th grade exam and proportion of non-attainment, defined as ‘results for 9th grade exam unavailable’. Data adjusted for sex, birth weight, parental age and parental level of education. Compared to controls, children with CL achieved higher scores (mean difference 0.12, 95% CI −0.05; 0.29) and children with CLP presented with lower scores (mean difference −0.06, 95% CI −0.21; 0.09), albeit both statistically insignificant. Children with CP achieved significantly lower scores, mean difference −0.20 (95% CI −0.38; −0.03). Odds ratios for non-attainment at final exam were: CL 0.79 (95% CI 0.46; 1.35), CLP 1.07 (95% CI 0.71; 1.61), CP 2.59 (95% CI 1.78; 3.76). Oral cleft type rather than number and timing of anesthesia and operations associate to poorer academic performance. Although a potential neurotoxic effect due to anesthetic agents is not reflected in the data it cannot be completely excluded.
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影响因子：
4
作者：
Hill, Nancy E.;Tyson, Diana F.
通讯作者：
Tyson, Diana F.
DOI：
10.1016/s0140-6736(15)00608-x
发表时间：
2016-01-16
期刊：
Lancet (London, England)
影响因子：
--
作者：
Davidson AJ;Disma N;de Graaff JC;Withington DE;Dorris L;Bell G;Stargatt R;Bellinger DC;Schuster T;Arnup SJ;Hardy P;Hunt RW;Takagi MJ;Giribaldi G;Hartmann PL;Salvo I;Morton NS;von Ungern Sternberg BS;Locatelli BG;Wilton N;Lynn A;Thomas JJ;Polaner D;Bagshaw O;Szmuk P;Absalom AR;Frawley G;Berde C;Ormond GD;Marmor J;McCann ME;GAS consortium
通讯作者：
GAS consortium
DOI：
10.1597/14-126
发表时间：
2015-07-01
期刊：
CLEFT PALATE-CRANIOFACIAL JOURNAL
影响因子：
--
作者：
Laub, Donald R., Jr.;Williams, Robert K.
通讯作者：
Williams, Robert K.
DOI：
10.1597/13-293
发表时间：
2015-05
期刊：
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
影响因子：
--
作者：
Knight J;Cassell CH;Meyer RE;Strauss RP
通讯作者：
Strauss RP
影响因子：
2.5
作者：
Johnson, S;Marlow, N
通讯作者：
Marlow, N