Virosome-based nanovaccines; a promising bioinspiration and biomimetic approach for preventing viral diseases: A review.
Virosome-based nanovaccines; a promising bioinspiration and biomimetic approach for preventing viral diseases: A review.
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DOI：
10.1016/j.ijbiomac.2021.04.005
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发表时间：
2021-07-01
影响因子：
8.2
通讯作者：
Gholami A
中科院分区：
文献类型：
--
作者：
Asadi K;Gholami A
接种疫苗是控制与传染病有关的发病率和死亡率的最有效手段。然而，由于病毒抗原的低免疫原性，纳米医学作为新一代疫苗发展的新机遇受到了研究者的鼓励。病毒体是FDA批准的纳米载体，具有抗病毒感染的生物灵感和仿生效力。用关键的病毒融合蛋白修饰病毒体表面是疫苗开发的基石。病毒体表面抗原创新性地与宿主细胞上的靶向受体相互作用，通过产生抗体的B细胞和内吞介导的途径内化来诱发体液或细胞免疫反应。迄今为止，几种基于病毒体制剂的纳米疫苗已经商业化，用于对抗广泛和危及生命的感染。近年来，针对新型严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）的病毒体疫苗平台的研制取得了巨大进展。本文综述了基于病毒体的纳米疫苗的制备、性质及其在SARS病毒性疾病中的应用，特别是其在SARS疫苗研发中的重要性。
Vaccination is the most effective means of controlling infectious disease-related morbidity and mortality. However, due to low immunogenicity of viral antigens, nanomedicine as a new opportunity in new generation of vaccine advancement attracted researcher encouragement. Virosome is a lipidic nanomaterial emerging as FDA approved nanocarriers with promising bioinspiration and biomimetic potency against viral infections. Virosome surface modification with critical viral fusion proteins is the cornerstone of vaccine development. Surface antigens at virosomes innovatively interact with targeted receptors on host cells that evoke humoral or cellular immune responses through antibody-producing B cell and internalization by endocytosis-mediated pathways. To date, several nanovaccine based on virosome formulations have been commercialized against widespread and life-threatening infections. Recently, Great efforts were made to fabricate a virosome-based vaccine platform against a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Thus, this review provides a novel overview of the virosome based nanovaccine production, properties, and application on the viral disease, especially its importance in SARS-CoV-2 vaccine discovery.
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影响因子：
7.3
作者：
Ebensen T;Debarry J;Pedersen GK;Blazejewska P;Weissmann S;Schulze K;McCullough KC;Cox RJ;Guzmán CA
通讯作者：
Guzmán CA
影响因子：
5.4
作者：
Dacoba, Tamara G.;Ruiz-Gaton, Luisa;Crecente-Campo, Jose
通讯作者：
Crecente-Campo, Jose
影响因子：
5.5
作者：
Bungener, L;Huckriede, A;Daemen, T
通讯作者：
Daemen, T
影响因子：
9.2
作者：
Amacker, Mario;Smardon, Charli;Fleury, Sylvain
通讯作者：
Fleury, Sylvain
影响因子：
6.2
作者：
Bovier, Patrick A.
通讯作者：
Bovier, Patrick A.