Carbon black and titanium dioxide nanoparticles induce distinct molecular mechanisms of toxicity.
Carbon black and titanium dioxide nanoparticles induce distinct molecular mechanisms of toxicity.
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DOI：
10.1002/wnan.1302
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发表时间：
2014-11
影响因子：
8.6
通讯作者：
Baeza-Squiban, Armelle
中科院分区：
文献类型：
--
作者：
Boland, Sonja;Hussain, Salik;Baeza-Squiban, Armelle
越来越多的证据表明纳米材料与不良生物后果有关，由于纳米材料的各种应用和潜在的人类接触，因此必须评估其毒性，以便对工人和消费者进行风险评估。了解其毒性的潜在机制至关重要，因为在不同纳米材料暴露后观察到的类似效应并不反映类似的细胞内处理和细胞器相互作用。深入了解机制不仅需要准确预测潜在的毒理学影响，而且还需要通过调节理化特性来开发更安全的纳米应用。此外，生物医学应用还可以利用关于纳米毒性作用模式的深入知识来设计新的纳米颗粒衍生药物。在本手稿中，我们讨论了炭黑和二氧化钛纳米颗粒暴露后的毒性分子途径的相似性和差异，并确定了这两种纳米颗粒诱导的主要毒性机制，这也可能是其他不溶性纳米材料的作用模式的指示。我们解决易位，细胞死亡诱导，遗传毒性和炎症诱导的二氧化钛和炭黑纳米粒子，这取决于他们的内化，活性氧产生能力和/或蛋白质相互作用。我们总结了它们独特的细胞毒性机制和关键步骤，这些步骤可能是有针对性的，以避免不良反应或诱导它们用于纳米医学目的。若干物理化学特性可能会影响此处描述的这些一般毒性途径，确定常见毒性途径可以支持纳米材料在毒性方面的分组。
Increasing evidence link nanomaterials with adverse biological outcomes and due to the variety of applications and potential human exposures to nanoparticles it is thus important to evaluate their toxicity for the risk assessment of workers and consumers. It is crucial to understand the underlying mechanisms of their toxicity as observation of similar effects after different nanomaterial exposures does not reflect similar intracellular processing and organelle interactions. A thorough understanding of mechanisms is not only needed for accurate prediction of potential toxicological impacts but also for the development of safer nanoapplications by modulating the physico-chemical characteristics. Furthermore biomedical applications may also take advantage of an in depth knowledge about the mode of action of nanotoxicity to design new nanoparticle-derived drugs. In the present manuscript we discuss the similarities and differences in molecular pathways of toxicity after carbon black and TiO2 nanoparticle exposures and identify the main toxicity mechanisms induced by these two nanoparticles which may also be indicative for the mode of action of other insoluble nanomaterials. We address the translocation, cell death induction, genotoxicity and inflammation induced by titanium dioxide and carbon black nanoparticles which depend on their internalisation, ROS production capacities and/or protein interactions. We summarise their distinct cellular mechanisms of toxicity and the crucial steps which may be targeted to avoid adverse effects or to induce them for nanomedical purposes. Several physico-chemical characteristics could influence these general toxicity pathways depicted here and the identification of common toxicity pathways could support the grouping of nanomaterials in terms of toxicity.
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影响因子：
10
作者：
Hussain S;Smulders S;De Vooght V;Ectors B;Boland S;Marano F;Van Landuyt KL;Nemery B;Hoet PH;Vanoirbeek JA
通讯作者：
Vanoirbeek JA
影响因子：
8.8
作者：
Koike, Eiko;Takano, Hirohisa;Kobayashi, Takahiro
通讯作者：
Kobayashi, Takahiro
影响因子：
3.7
作者：
Ale-Agha, Niloofar;Albrecht, Catrin;Klotza, Lars-Oliver
通讯作者：
Klotza, Lars-Oliver
影响因子：
3.9
作者：
Deng, Zhou J.;Butcher, Neville J.;Minchin, Rodney F.
通讯作者：
Minchin, Rodney F.
影响因子：
18.3
作者：
Kreyling, Wolfgang G.;Semmler-Behnke, Manuela;Takenaka, Shinji;Moeller, Winfried
通讯作者：
Moeller, Winfried