Non-cystic macular thickening on optical coherence tomography as an alternative to fluorescein angiography for predicting retinal vascular leakage in early stages of uveitis.
Non-cystic macular thickening on optical coherence tomography as an alternative to fluorescein angiography for predicting retinal vascular leakage in early stages of uveitis.
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DOI：
10.1038/s41598-022-17701-2
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发表时间：
2022-08-05
影响因子：
4.6
通讯作者：
Modjtahedi, Bobeck S.
中科院分区：
文献类型：
--
作者：
Ebrahimiadib, Nazanin;Kianzad, Zahra;Zarei, Mohammad;Davoudi, Samaneh;Riazi-Esfahani, Hamid;Bazvand, Fatemeh;Mahdizad, Zahra;Modjtahedi, Bobeck S.
目的探讨葡萄膜炎患者光学相干断层扫描（OCT）显示黄斑部非囊性增厚与荧光素血管造影（FA）显示视网膜血管渗漏的关系。葡萄膜炎门诊患者的横断面研究。任何程度的炎症细胞在前玻璃体的患者，只要没有黄斑囊肿或视网膜下液或黄斑萎缩观察OCT。OCT功能和最佳矫正视力（BCVA），炎症程度和FA结果之间的相关性进行了检查。FA中血管渗漏的严重程度按视神经、黄斑、后部和外周渗漏分级。我们使用广义估计方程来评估黄斑厚度和体积与血管造影评分之间的关系。共有43例患者（100项检查数据）符合入选标准。OCT参数（黄斑中心厚度、3 mm和6 mm中心凹周围黄斑厚度以及总黄斑体积和中心黄斑体积）与血管造影评分（黄斑、视盘、后部和外周血管渗漏评分）之间存在显著相关性（所有P值均< 0.0001）。中心凹周围6 mm厚度与周围血管渗漏评分的相关性（R = 0.76; P < 0.001）强于CMT与该血管造影评分的相关性（R = 0.69; P < 0.001）。OCT上黄斑的非囊性增厚，尤其是在中心凹周围区域，是葡萄膜炎患者存在视网膜血管渗漏的可靠预测因素。
To evaluate the relationship between non-cystic thickening of the macula on optical coherence tomography (OCT) and retinal vascular leakage on fluorescein angiogram (FA) in patients with uveitis. A cross-sectional study of patients seen in the uveitis clinic. Patients with any degree of inflammatory cells in the anterior vitreous were included, provided that no macular cyst or subretinal fluid or macular atrophy was observed in OCT. The correlation between OCT features and best corrected visual acuity (BCVA), the degree of inflammation, and FA findings were examined. The severity of vascular leakage in FA was graded for optic nerve, macula and posterior and peripheral leakage. We used generalized estimation equation to assess the associations between macular thickness and volume with angiographic scores. A total of 43 patients (100 exam data) met inclusion criteria. There was a significant relationship between OCT parameters (central macular thickness, 3 mm and 6 mm perifoveal macular thickness as well as total and central macular volume) with angiographic scores (macular, optic disc, posterior and peripheral vascular leakage score) (all P values < 0.0001). The correlation between the 6 mm perifoveal thickness and peripheral vascular leakage score (R = 0.76; P < 0.001) was stronger than the correlation of CMT with this angiographic score (R = 0.69; P < 0.001). Non-cystic thickening of the macula on OCT, especially in perifoveal area, is a reliable predictor of the presence of retinal vascular leakage in patients with uveitis.
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影响因子：
5.1
作者：
Rosenbaum JT;Sibley CH;Lin P
通讯作者：
Lin P
影响因子：
4.2
作者：
Castellano, Chelsea G.;Stinnett, Sandra S.;Jaffe, Glenn J.
通讯作者：
Jaffe, Glenn J.
影响因子：
4.1
作者：
Knickelbein, Jared E.;Tucker, William;Sen, H. Nida
通讯作者：
Sen, H. Nida
影响因子：
4.6
作者：
Zarei M;Pesarakli H;Yaseri M;Etesali H;Ebrahimiadib N
通讯作者：
Ebrahimiadib N
影响因子：
4.1
作者：
Durrani, OM;Tehrani, NN;Murray, PI
通讯作者：
Murray, PI