Multisite reliability of cognitive BOLD data.
Multisite reliability of cognitive BOLD data.
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DOI：
10.1016/j.neuroimage.2010.09.076
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发表时间：
2011-02-01
期刊：
影响因子：
5.7
通讯作者：
Function Biomedical Informatics Research Network
中科院分区：
文献类型：
--
作者：
Brown GG;Mathalon DH;Stern H;Ford J;Mueller B;Greve DN;McCarthy G;Voyvodic J;Glover G;Diaz M;Yetter E;Ozyurt IB;Jorgensen KW;Wible CG;Turner JA;Thompson WK;Potkin SG;Function Biomedical Informatics Research Network
研究者进行多部位功能性磁共振成像研究，以增加统计功效，增强概括性，并提高相关亚组的抽样可能性。然而，成像方法中不期望的部位变化可能抵消这些潜在的优点。我们使用方差分量分析，以调查的变化来源的血氧水平依赖（BOLD）信号在四个3T磁体的体素和感兴趣的区域（ROI）分析。18名参与者前往4个磁铁地点，完成8次涉及情绪或中性分心的工作记忆任务。人的方差是10倍以上的网站方差的六个投资回报率研究。然而，个人与网站的互动对总数产生了相当大的不必要的差异。平均运行增加了站点间的可靠性，许多体素显示良好到优秀的站点间的可靠性时，八个运行的平均值和感兴趣的区域显示公平到良好的可靠性。除了平均运行次数外，研究中心间可靠性还取决于分析的特定功能对比。虽然中位效应大小与站点间可靠性相关，但许多体素观察到分离。合并效应量较大但站点间可靠性较差的脑区域与个体差异减少相关。合并效应量较小但站点间可靠性极佳的大脑区域与始终显示积极或消极BOLD反应的参与者的平衡相关。虽然BOLD数据的站点间可靠性可以是好到优秀，但获得高度可靠的数据需要强大的激活范例，持续的质量保证和仔细的实验控制。
Investigators perform multi-site functional magnetic resonance imaging studies to increase statistical power, to enhance generalizability, and to improve the likelihood of sampling relevant subgroups. Yet undesired site variation in imaging methods could off-set these potential advantages. We used variance components analysis to investigate sources of variation in the blood oxygen level dependent (BOLD) signal across four 3T magnets in voxelwise and region of interest (ROI) analyses. Eighteen participants traveled to four magnet sites to complete eight runs of a working memory task involving emotional or neutral distraction. Person variance was more than 10 times larger than site variance for five of six ROIs studied. Person-by-site interactions, however, contributed sizable unwanted variance to the total. Averaging over runs increased between-site reliability, with many voxels showing good to excellent between-site reliability when eight runs were averaged and regions of interest showing fair to good reliability. Between-site reliability depended on the specific functional contrast analyzed in addition to the number of runs averaged. Although median effect size was correlated with between-site reliability, dissociations were observed for many voxels. Brain regions where the pooled effect size was large but between-site reliability was poor were associated with reduced individual differences. Brain regions where the pooled effect size was small but between-site reliability was excellent were associated with a balance of participants who displayed consistently positive or consistently negative BOLD responses. Although between-site reliability of BOLD data can be good to excellent, acquiring highly reliable data requires robust activation paradigms, ongoing quality assurance, and careful experimental control.
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影响因子：
1.3
作者：
COLLINS, DL;NEELIN, P;EVANS, AC
通讯作者：
EVANS, AC
影响因子：
1.7
作者：
Costafreda, Sergi G.;Khanna, Akash;Fu, Cynthia H. Y.
通讯作者：
Fu, Cynthia H. Y.
DOI：
10.1007/s10334-008-0119-1
发表时间：
2008-08-01
影响因子：
2.3
作者：
De Guio, Francois;Benoit-Cattin, Hugues;Davenel, Armel
通讯作者：
Davenel, Armel
影响因子：
5.7
作者：
Friedman, Lee;Glover, Gary H.
通讯作者：
Glover, Gary H.
影响因子：
4.8
作者：
Friedman, Lee;Stern, Hal;Potkin, Steven G.
通讯作者：
Potkin, Steven G.