Effect of fluid resuscitation on cerebral integrity: A prospective randomised porcine study of haemorrhagic shock.

Effect of fluid resuscitation on cerebral integrity: A prospective randomised porcine study of haemorrhagic shock.
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液体复苏对脑完整性的影响:失血性休克的前瞻性随机猪研究

DOI:
10.1097/eja.0000000000001416
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发表时间:
2021
影响因子:
3.6
通讯作者:
Hartmann E.K.
Hartmann E.K.
中科院分区:
医学2区
文献类型:
--
作者:
Ziebart A;Möllmann C;Garcia-Bardon A;Kamuf J;Schäfer M;Thomas R;Hartmann E.K.

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出血性休克的治疗是一项具有挑战性的任务。胶体已被视为标准治疗,但其安全性和益处一直是有争议的辩论主题。负面影响,包括肾衰竭和死亡率增加,导致其管理的限制。不同输注方案对脑的影响在很大程度上是未知的。实验方法本研究探讨了明胶-聚琥珀酸酯、羟乙基淀粉(HES)和平衡电解质溶液(BES)对猪脑完整性的影响,重点是脑炎症、细胞凋亡和血流量。设计
BACKGROUNDThe treatment of haemorrhagic shock is a challenging task. Colloids have been regarded as standard treatment, but their safety and benefit have been the subject of controversial debates. Negative effects, including renal failure and increased mortality, have resulted in restrictions on their administration. The cerebral effects of different infusion regimens are largely unknown.OBJECTIVESThe current study investigated the impact of gelatine-polysuccinate, hydroxyethyl starch (HES) and balanced electrolyte solution (BES) on cerebral integrity, focusing on cerebral inflammation, apoptosis and blood flow in pigs.DESIGN
DOI: 10.1186/s13049-018-0477-2
发表时间: 2018-02-09
期刊: Scandinavian journal of trauma, resuscitation and emergency medicine
影响因子: --
作者:
Ziebart A;Möllmann C;Garcia-Bardon A;Kamuf J;Schäfer M;Thomas R;Hartmann EK
通讯作者: Hartmann EK
DOI: --
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影响因子: 2.9
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发表时间: 2019
期刊: Der Radiologe
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通讯作者: Prof. Dr. M. Bock
DOI: --
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期刊: Der Anaesthesist
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作者:
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通讯作者: K. Hofmann
DOI: --
发表时间: 2016
影响因子: 3.2
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