Reactive oxygen species at the crossroads of inflammasome and inflammation.
Reactive oxygen species at the crossroads of inflammasome and inflammation.
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DOI：
10.3389/fphys.2014.00352
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发表时间：
2014
影响因子：
4
通讯作者：
Natarajan V
中科院分区：
文献类型：
--
作者：
Harijith A;Ebenezer DL;Natarajan V
炎症体是先天免疫系统的重要组成部分。这些是由细胞内传感器与半胱氨酸天冬氨酸氨基转移酶和白介素酶激活系统组成的多蛋白低聚物平台。NOD样受体蛋白(NLRP)3和6以及NLRC4和AIM2是炎症体家族中的重要成员。炎性小体激活导致下垂，这是一种不同于细胞凋亡的程序性死亡过程，通过激活Caspase和进一步的下游靶子如IL-1β和IL-18导致炎症级联反应的激活。活性氧(ROS)是重要的炎症体激活信号。ROS通过丝裂原活化蛋白激酶(MAPK)和细胞外信号调节蛋白激酶1和2(ERK1/2)激活炎症体。炎性小体调节失调在多种病理过程中起着重要作用。登革热和呼吸道合胞病毒等病毒感染会激活炎性小体。矽肺和痛风中的晶体化合物也能激活ROS。在糖尿病中，抑制自噬，导致功能障碍的线粒体积累，导致激活炎性小体的ROS产生增加。炎症小体的激活可以被抗氧化剂如SIRT-1抑制。炎症体及其相关的级联反应可作为各种病理条件的未来治疗靶点。
Inflammasomes form a crucial part of the innate immune system. These are multi-protein oligomer platforms that are composed of intracellular sensors which are coupled with caspase and interleukin activating systems. Nod-like receptor protein (NLRP) 3, and 6 and NLRC4 and AIM2 are the prominent members of the inflammasome family. Inflammasome activation leads to pyroptosis, a process of programmed cell death distinct from apoptosis through activation of Caspase and further downstream targets such as IL-1β and IL-18 leading to activation of inflammatory cascade. Reactive oxygen species (ROS) serves as important inflammasome activating signals. ROS activates inflammasome through mitogen-activated protein kinases (MAPK) and extracellular signal-regulated protein kinases 1 and 2 (ERK1/2). Dysregulation of inflammasome plays a significant role in various pathological processes. Viral infections such as Dengue and Respiratory syncytial virus activate inflammasomes. Crystal compounds in silicosis and gout also activate ROS. In diabetes, inhibition of autophagy with resultant accumulation of dysfunctional mitochondria leads to enhanced ROS production activating inflammasomes. Activation of inflammasomes can be dampened by antioxidants such as SIRT-1. Inflammasome and related cascade could serve as future therapeutic targets for various pathological conditions.
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影响因子：
8.7
作者：
Broz P;Monack DM
通讯作者：
Monack DM
DOI：
10.1046/j.1432-1033.2002.03002.x
发表时间：
2002-07-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Doussiere, J;Bouzidi, F;Vignais, PV
通讯作者：
Vignais, PV
影响因子：
82.9
作者：
Flach, Tracy L.;Ng, Gilbert;Shi, Yan
通讯作者：
Shi, Yan
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
5.4
作者：
Franchi, Luigi;Nunez, Gabriel
通讯作者：
Nunez, Gabriel