A protective role of Mer receptor tyrosine kinase in nephrotoxic serum-induced nephritis.
A protective role of Mer receptor tyrosine kinase in nephrotoxic serum-induced nephritis.
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DOI：
10.1016/j.clim.2010.04.002
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发表时间：
2010-08
期刊：
影响因子：
--
通讯作者：
Cohen PL
中科院分区：
文献类型：
--
作者：
Shao WH;Zhen Y;Rosenbaum J;Eisenberg RA;McGaha TL;Birkenbach M;Cohen PL
Mer受体酪氨酸激酶在肾小球中强烈表达。我们想知道这种分子是否可能通过其作为凋亡细胞受体和免疫调节分子的功能来改变免疫介导的肾小球疾病。注射NTS后第3天，与野生型（WT）小鼠相比，Mer敲除（KO）小鼠的存活率降低，蛋白尿和血清尿素水平显著升高。他们的肾小球增生，后来变成坏死。而在WT小鼠肾小球中，观察到Mer表达显著增加。凋亡小体在NTS处理的Mer-KO肾脏中明显，但在正常对照中不明显。NTS处理的Mer-KO小鼠具有大量中性粒细胞浸润和炎性细胞因子表达。因此，Mer作为凋亡细胞的受体和下调炎症的分子，在减轻肾脏炎症中具有关键作用。
The Mer receptor tyrosine kinase is strongly expressed in the glomerulus. We wondered if this molecule might modify immune-mediated glomerular disease through its functions as a receptor for apoptotic cells and immunoregulatory molecule. Mer-knockout (KO) mice showed decreased survival rate and greatly increased proteinuria and serum urea levels compared to wild type (WT) mice by day 3 after injection of NTS. Their glomeruli were hyperplastic and later became necrotic. While in the glomerulus of WT mice, a significant increase of Mer expression was observed. Apoptotic bodies were evident in NTS-treated Mer-KO kidneys, but not in normal controls. NTS-treated Mer-KO mice had massive neutrophil infiltration and inflammatory cytokine expression. Mer thus has a critical role in attenuating renal inflammation, both as a receptor for apoptotic cells and as a molecule that down regulates inflammation.
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影响因子：
19.6
作者：
Kim, JH;Ha, IS;Park, WY
通讯作者：
Park, WY
影响因子：
5.4
作者：
Behrens, EM;Gadue, P;Cohen, PL
通讯作者：
Cohen, PL
DOI：
10.1046/j.1365-2613.1998.00080.x
发表时间：
1998-12-01
影响因子：
3
作者：
Ryffel, B;Eugster, H;Le Hir, M
通讯作者：
Le Hir, M
影响因子：
2.6
作者：
Aringer, M;Smolen, JS
通讯作者：
Smolen, JS
影响因子：
3.5
作者：
D'Cruz, PM;Yasumura, D;Vollrath, D
通讯作者：
Vollrath, D