Relationships between histogram analysis of ADC values and complex 18F-FDG-PET parameters in head and neck squamous cell carcinoma.
Relationships between histogram analysis of ADC values and complex 18F-FDG-PET parameters in head and neck squamous cell carcinoma.
复制标题
头颈鳞状细胞癌ADC值与复杂18F-FDG-PET参数的直方图分析之间的关系。
DOI：
10.1371/journal.pone.0202897
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Surov A
中科院分区：
文献类型：
--
作者：
Meyer HJ;Purz S;Sabri O;Surov A
Histogram analysis is an emergent imaging technique to further analyze radiological images and to obtain imaging biomarker. In head and neck cancer, MRI and PET are routinely used in clinical practice. The aim of this study was to analyze associations between histogram based ADC parameters and complex FDG-PET derived parameters in head and neck squamous cell carcinoma (HNSCC). 34 patients (26% female, mean age, 56.7 ± 10.2 years) with primary HNSCC were prospectively included into the study. ADC histogram parameters were calculated by inhouse made matlab software using a whole lesion measurement. For each tumor, maximum and mean standardized uptake values (SUVmax, SUVmean), Total Lesion Glycolysis (TLG) and Metabolic Tumor Volume (MTV) were determined on PET-images. Spearman's correlation coefficient (ρ) was used to analyze associations between investigated parameters. Benjamini-Hochberg correction was used to adjust for multiple testing. Mann-Whitney test was used for group discrimination. P-values < 0.05 were taken to indicate statistical significance. The correlation analysis in the whole tumor group revealed a statistically significant correlation between entropy and MTV as well as TLG (ρ = 0.67, P<0.0001 and ρ = 0.61, P = 0.0002 respectively). There were statistically significant differences between T1/2 and T3/4 tumors in the following parameters: entropy (2.07 ± 0.36 vs 2.61 ± 0.43, P = 0.007), SUVmax (10.79 ± 4.13 vs 17.93 ± 5.89, P = 0.007), SUVmean (6.39 ± 2.48 vs 9.81 ± 4.49, P = 0.01), SUVmin (4.09 ± 1.57 vs 6.34 ± 2.59, P = 0.03), MTV (9.50 ± 7.92 vs 20.36 ± 13.30, P = 0.02), TGU (55.97 ± 39.09 vs 212.3 ± 186.3, P = 0.002). This study showed that entropy derived from ADC maps is strongly associated with MTV and TLG in HNSCC. Entropy, SUVmax, SUVmean, TLG and MTV were statistically significant higher in T3/4 tumors in comparison to T1/2 carcinomas.
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影响因子：
3.1
作者：
Schob, Stefan;Meyer, Hans Jonas;Surov, Alexey
通讯作者：
Surov, Alexey
同时 18F-FDG-PET/MRI： 头颈部鳞状细胞癌患者的弥散、葡萄糖代谢和组织病理学参数之间的关系
影响因子：
4.8
作者：
Surov, Alexey;Stumpp, Patrick;Purz, Sandra
通讯作者：
Purz, Sandra
影响因子：
2.5
作者：
Meyer, Hans Jonas;Leifels, Leonard;Surov, Alexey
通讯作者：
Surov, Alexey
影响因子：
--
作者：
Leifels L;Purz S;Stumpp P;Schob S;Meyer HJ;Kahn T;Sabri O;Surov A
通讯作者：
Surov A
DOI：
10.1016/j.mric.2017.08.010
发表时间：
2018-02-01
影响因子：
1.6
作者：
Galgano, Samuel J.;Marshall, Ryan V.;Bhambhvani, Pradeep
通讯作者：
Bhambhvani, Pradeep