Impact of surgical excision of lesions on pain in a rat model of endometriosis.
Impact of surgical excision of lesions on pain in a rat model of endometriosis.
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DOI：
10.1002/ejp.527
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发表时间：
2015-01
影响因子：
3.6
通讯作者：
Levine, J. D.
中科院分区：
文献类型：
--
作者：
Alvarez, P.;Giudice, L. C.;Levine, J. D.
慢性疼痛是子宫内膜异位症最常见和致残的特征。手术切除子宫内膜异位症病灶可以缓解疼痛，但疼痛复发是常见的。对子宫内膜异位症临床前模型的研究可能有助于阐明异位病灶作为疼痛来源的作用。因此，我们在子宫内膜异位症疼痛的临床前模型中评估了病灶切除对机械性痛觉过敏的影响。通过将自体子宫组织植入腓肠肌诱导子宫内膜异位症。在植入后的不同时间对囊性病变进行手术切除或抽吸引流，并在病变部位评估机械伤害性阈值。植入后2周、8周和16周的病变产生了相似程度的机械性痛觉过敏（n = 6/组）。病变切除（n = 6/组）产生了较长的抑制，其幅度和时间过程取决于切除的时间。在2周和8周切除产生了一个快速发作显着衰减的痛觉过敏，术后3周恢复到切除前的值。相反，在16周时切除病变，在切除后2周产生抑制痛觉过敏的峰值，但随后抑制持续。从病变囊肿中抽吸液体可短暂减弱机械性痛觉过敏（n = 6/组）。在这个临床前模型中，我们证明了异位病灶的手术切除或囊肿引流可以减轻子宫内膜异位症疼痛，为临床观察子宫内膜异位症疼痛依赖于病灶的持续存在提供了支持。
Chronic pain is the most common and disabling feature of endometriosis. Surgical excision of endometriosis lesions provides relief but pain relapse is common. Studies in a preclinical model of endometriosis might help to unravel the role of the ectopic lesions as the source of pain. Thus, we evaluated the impact of lesion excision on mechanical hyperalgesia in a preclinical model of endometriosis pain. Endometriosis was induced by implanting autologous uterine tissue onto the gastrocnemius muscle. Surgical excision or aspiration drainage of the cystic lesion was performed at different times post-implant and mechanical nociceptive thresholds assessed at the site of the lesion. Lesions at 2, 8 and 16 weeks post-implant, produced mechanical hyperalgesia of similar magnitude (n = 6/group). Excision of lesions (n = 6/group) produced a longer inhibition, with a magnitude and time-course depending on the timing of excision. Excision at 2 and 8 weeks produced a rapid onset marked attenuation of hyperalgesia, which returned to pre-excision values by postsurgical week 3. In contrast, excision of the lesion at 16 weeks produced a peak of inhibition of hyperalgesia 2 weeks post-excision, but then the inhibition was sustained. Aspiration of fluid from cysts in the lesions briefly attenuated mechanical hyperalgesia (n = 6/group). In this preclinical model we demonstrate that endometriosis pain is alleviated by surgical excision of the ectopic lesion or drainage of its cysts, providing support for the clinical observation that endometriosis pain is dependent on the ongoing presence of the lesions.
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影响因子：
7.2
作者：
Falcone, Tommaso;Lebovic, Dan I.
通讯作者：
Lebovic, Dan I.
影响因子：
2.1
作者：
Berlanda, Nicola;Vercellini, Paolo;Fedele, Luigi
通讯作者：
Fedele, Luigi
影响因子：
--
作者：
MARCONDES, F. K.;BIANCHI, F. J.;TANNO, A. P.
通讯作者：
TANNO, A. P.
影响因子：
1.2
作者：
Dargin, James M.;Lowenstein, Robert A.
通讯作者：
Lowenstein, Robert A.
影响因子：
7.4
作者：
McAllister SL;McGinty KA;Resuehr D;Berkley KJ
通讯作者：
Berkley KJ