Harnessing self-assembled peptide nanoparticles in epitope vaccine design.
Harnessing self-assembled peptide nanoparticles in epitope vaccine design.
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DOI：
10.1016/j.biotechadv.2017.05.002
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发表时间：
2017-09
影响因子：
16
通讯作者：
Ghasemi Y
中科院分区：
文献类型：
--
作者：
Negahdaripour M;Golkar N;Hajighahramani N;Kianpour S;Nezafat N;Ghasemi Y
疫苗接种是医学史上最成功的突破之一。近年来，基于表位的亚单位疫苗被引入作为传统疫苗的更安全的替代品。然而，它们具有有限的免疫原性。纳米技术在解决这一问题方面显示出了价值。不同种类的纳米疫苗已被采用，其中病毒样纳米颗粒（VLP）和自组装肽纳米颗粒（SAPNs）似乎是非常有前途的。近来，SAPNs由于其独特的性质，包括分子特异性、生物降解性和生物相容性，引起了特别的兴趣。它们在大小上也类似于病原体。它们的多价性允许抗原在其表面有序重复展示，从而诱导比单一免疫原更强的免疫反应。在疫苗设计中，SAPN自身佐剂性被认为是一个突出的优势，因为不再需要使用毒性佐剂。SAPN通常由螺旋或β-折叠二级结构组成，并且由天然肽或从头结构定制。亚基选择的灵活性为具有不同特征的各种分子打开了大门。SAPN工程是一个新兴的领域，预计在未来会产生更多的新结构，特别是随着相关计算工具的快速发展。本综述的目的是提供一个国家的最先进的概述自组装肽纳米粒子及其在疫苗设计中的使用在最近的研究。此外，他们的设计原则和应用程序的计算方法疫苗设计进行了总结。
Vaccination has been one of the most successful breakthroughs in medical history. In recent years, epitope-based subunit vaccines have been introduced as a safer alternative to traditional vaccines. However, they suffer from limited immunogenicity. Nanotechnology has shown value in solving this issue. Different kinds of nanovaccines have been employed, among which virus-like nanoparticles (VLPs) and self-assembled peptide nanoparticles (SAPNs) seem very promising. Recently, SAPNs have attracted special interest due to their unique properties, including molecular specificity, biodegradability, and biocompatibility. They also resemble pathogens in terms of their size. Their multivalency allows an orderly repetitive display of antigens on their surface, which induces a stronger immune response than single immunogens. In vaccine design, SAPN self-adjuvanticity is regarded an outstanding advantage, since the use of toxic adjuvants is no longer required. SAPNs are usually composed of helical or β-sheet secondary structures and are tailored from natural peptides or de novo structures. Flexibility in subunit selection opens the door to a wide variety of molecules with different characteristics. SAPN engineering is an emerging area, and more novel structures are expected to be generated in the future, particularly with the rapid progress in related computational tools. The aim of this review is to provide a state-of-the-art overview of self-assembled peptide nanoparticles and their use in vaccine design in recent studies. Additionally, principles for their design and the application of computational approaches to vaccine design are summarized.
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DOI：
10.1093/protein/14.8.529
发表时间：
2001-08-01
期刊：
PROTEIN ENGINEERING
影响因子：
--
作者：
Arai, R;Ueda, H;Nagamune, T
通讯作者：
Nagamune, T
影响因子：
2.7
作者：
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通讯作者：
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DOI：
10.1007/978-1-4939-2131-7_5
发表时间：
2015-01-01
期刊：
PROTEIN CAGES: METHODS AND PROTOCOLS
影响因子：
--
作者：
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通讯作者：
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DOI：
10.1155/2011/126794
发表时间：
2011
期刊：
Influenza research and treatment
影响因子：
--
作者：
Babapoor S;Neef T;Mittelholzer C;Girshick T;Garmendia A;Shang H;Khan MI;Burkhard P
通讯作者：
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影响因子：
6.2
作者：
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通讯作者：
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