International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature.

International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature.
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DOI:
10.1016/j.cgh.2022.02.017
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发表时间:
2022-11
期刊:
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
影响因子:
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其他
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嗜酸粒细胞性胃肠道疾病 (EGID) 所使用的术语存在很大的异质性,特别是笼统的术语“嗜酸粒细胞性胃肠炎”,限制了临床和研究的进展。我们的目标是就标准化 EGID 命名法达成国际共识。该共识过程采用了德尔菲法。最初的命名框架被提出并以迭代方式完善,然后在第一轮德尔福投票中进行评估。结果在两次共识会议上进行了讨论,更新了框架,并在第二次德尔福投票中重新评估,并设定了 70% 的同意门槛。在参与的 91 名专家中,85 名 (93%) 完成了第一次德尔福调查,82 名 (90%) 完成了第二次德尔福调查。除两项声明外,所有声明均达成共识。 “EGID”是在没有继发原因的情况下胃肠道嗜酸性粒细胞炎症疾病的首选总称(100% 一致)。涉及的胃肠道段将被专门命名并使用“Eo”缩写惯例:嗜酸细胞性胃炎(现在缩写为EoG)、嗜酸细胞性肠炎(EoN)和嗜酸细胞性结肠炎(EoC)。 “嗜酸性粒细胞性胃肠炎”一词不再作为总名称的首选(96% 一致)。当涉及 >2 个胃肠道区域时,名称应反映所有涉及的区域。这一国际进程就临床和研究用途的更新 EGID 命名法达成了共识。 EGID 将成为总称,而不是“嗜酸性粒细胞性胃肠炎”,并且建议根据胃肠道受累部位采用具体的命名惯例。随着更多数据的开发,该框架可以更新以反映最佳实践和基础科学。
Substantial heterogeneity in terminology used for eosinophilic gastrointestinal diseases (EGID), particularly the catchall term “eosinophilic gastroenteritis”, limits clinical and research advances. We aimed to achieve an international consensus for standardized EGID nomenclature. This consensus process utilized Delphi methodology. An initial naming framework was proposed and refined in iterative fashion, then assessed in a first round of Delphi voting. Results were discussed in two consensus meetings, the framework was updated, and re-assessed in a second Delphi vote, with a 70% threshold set for agreement. Of 91 experts participating, 85 (93%) completed the first and 82 (90%) completed the second Delphi surveys. Consensus was reached on all but two statements. “EGID” was the preferred umbrella term for disorders of GI tract eosinophilic inflammation in the absence of secondary causes (100% agreement). Involved GI tract segments will be named specifically and use an “Eo” abbreviation convention: eosinophilic gastritis (now abbreviated EoG), eosinophilic enteritis (EoN), and eosinophilic colitis (EoC). The term “eosinophilic gastroenteritis” is no longer preferred as the overall name (96% agreement). When >2 GI tract areas are involved, the name should reflect all of the involved areas. This international process resulted in consensus for updated EGID nomenclature for both clinical and research use. EGID will be the umbrella term rather than “eosinophilic gastroenteritis”, and specific naming conventions by location of GI tract involvement are recommended. As more data are developed, this framework can be updated to reflect best practices and the underlying science.
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