Neuroprotection: lessons from hibernators.
Neuroprotection: lessons from hibernators.
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DOI：
10.1016/j.cbpb.2012.01.008
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发表时间：
2012-05
影响因子：
2.2
通讯作者：
Drew, Kelly L.
中科院分区：
文献类型：
--
作者：
Dave, Kunjan R.;Christian, Sherri L.;Perez-Pinzon, Miguel A.;Drew, Kelly L.
冬眠的哺乳动物经历极端的代谢状态和体温，因为它们在体温正常（一种类似于典型温血哺乳动物的状态）和长时间的麻木（一种假死状态，其中大脑接收低至正常脑血流量的10%）之间过渡。进入和脱离麻木状态比麻木状态本身的极端代谢抑制和寒冷的体温更具生理挑战性。冬眠的哺乳动物表现出前所未有的耐受脑缺血的能力，脑缺血是由中风、心脏骤停或脑外伤引起的大脑血流量减少。虽然脑缺血通常会导致人类和大多数其他哺乳动物死亡或残疾，但当冬眠期间流向大脑的血流量急剧减少或在低温期间实验诱导时，冬眠的哺乳动物不会受到不良影响。这些动物，作为成年人，也显示出快速和明显的突触灵活性，其中突触在麻木期间缩回，并在唤醒时迅速重新出现。多种协调适应有助于这些动物对脑缺血的耐受。在这篇综述中，我们讨论了适应在变温哺乳动物，可能会提出新的治疗目标和策略，以保护人类大脑对脑缺血性损伤和神经退行性疾病。
Mammals that hibernate experience extreme metabolic states and body temperatures as they transition between euthermia, a state resembling typical warm blooded mammals, and prolonged torpor, a state of suspended animation where the brain receives as low as 10% of normal cerebral blood flow. Transitions into and out of torpor are more physiologically challenging than the extreme metabolic suppression and cold body temperatures of torpor per se. Mammals that hibernate show unprecedented capacities to tolerate cerebral ischemia, a decrease in blood flow to the brain caused by stroke, cardiac arrest or brain trauma. While cerebral ischemia often leads to death or disability in humans and most other mammals, hibernating mammals suffer no ill effects when blood flow to the brain is dramatically decreased during torpor or experimentally induced during euthermia. These animals, as adults, also display rapid and pronounced synaptic flexibility where synapses retract during torpor and rapidly re-emerge upon arousal. A variety of coordinated adaptations contribute to tolerance of cerebral ischemia in these animals. In this review we discuss adaptations in heterothermic mammals that may suggest novel therapeutic targets and strategies to protect the human brain against cerebral ischemic damage and neurodegenerative disease.
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影响因子：
2.5
作者：
Anderson, TR;Jarvis, CR;Andrew, RD
通讯作者：
Andrew, RD
DOI：
10.1097/00004647-200204000-00003
发表时间：
2002-04-01
影响因子：
6.3
作者：
Bernaudin, M;Nedelec, AS;Schumann-Bard, P
通讯作者：
Schumann-Bard, P
DOI：
10.1073/pnas.121119298
发表时间：
2001-06-05
影响因子：
11.1
作者：
Alonso, AD;Zaidi, T;Iqbal, K
通讯作者：
Iqbal, K
DOI：
10.1016/0742-8413(95)00000-3
发表时间：
1995-09-01
期刊：
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY
影响因子：
--
作者：
ATANASSOV, CL;NAEGELI, HU;VANREGENMORTEL, MHV
通讯作者：
VANREGENMORTEL, MHV
影响因子：
4.1
作者：
BOVERIS, A;CHANCE, B
通讯作者：
CHANCE, B