The role of Rho GTPase family in cochlear hair cells and hearing.
The role of Rho GTPase family in cochlear hair cells and hearing.
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DOI：
10.4103/1673-5374.369101
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发表时间：
2023-10
影响因子：
6.1
通讯作者：
Gong J
中科院分区：
文献类型：
--
作者：
Dai YB;Gao X;Liu D;Gong J
Rho GTP酶是肌动蛋白细胞骨架的重要调节因子。它们参与多种生理生化过程，如细胞骨架动力学的调节、发育、增殖、存活和再生等。在耳蜗毛细胞的发育过程中，Rho GTP酶被各种细胞外信号通过膜受体激活，进一步刺激多个下游效应器。具体地说，RhoA、CDC42和rac1是Rho GTP酶家族经典亚家族的成员，它们通过诱导肌动蛋白单体聚合和稳定肌动蛋白细丝来调节纤毛的发育和维持。此外，它们还调节听觉毛细胞中纤毛束的正常形态取向，这是细胞极性调节的重要因素。此外，RhoA、CDC42和rac1介导的肌动蛋白相关通路也在外毛细胞的运动中发挥作用，表明Rho GTP酶的功能在高极性听觉感觉系统中起着至关重要的作用。本文就RhoA、CDC42和rac1在耳蜗毛细胞中的表达以及这些小分子如何参与纤毛束形态发生和耳蜗毛细胞运动进行综述。我们还讨论了目前研究这些小分子作为治疗耳聋的药物靶点的研究进展。
Rho GTPases are essential regulators of the actin cytoskeleton. They are involved in various physiological and biochemical processes such as the regulation of cytoskeleton dynamics, development, proliferation, survival, and regeneration. During the development of cochlear hair cells, Rho GTPases are activated by various extracellular signals through membrane receptors to further stimulate multiple downstream effectors. Specifically, RhoA, Cdc42, and Rac1, members of the classical subfamily of the Rho GTPase family, regulate the development and maintenance of cilia by inducing the polymerization of actin monomers and stabilizing actin filaments. In addition, they also regulate the normal morphology orientation of ciliary bundles in auditory hair cells, which is an important element of cell polarity regulation. Moreover, the actin-related pathways mediated by RhoA, Cdc42, and Rac1 also play a role in the motility of outer hair cells, indicating that the function of Rho GTPases is crucial in the highly polar auditory sensory system. In this review, we focus on the expression of RhoA, Cdc42, and Rac1 in cochlear hair cells and how these small molecules participate in ciliary bundle morphogenesis and cochlear hair cell movement. We also discuss the progress of current research investigating the use of these small molecules as drug targets for deafness treatment.
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影响因子：
10.5
作者：
Habas, R;Dawid, IB;He, X
通讯作者：
He, X
影响因子：
4.5
作者：
Michalski, Nicolas;Petit, Christine
通讯作者：
Petit, Christine
DOI：
10.1523/jneurosci.3998-09.2009
发表时间：
2009-12-16
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
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通讯作者：
Lu X
影响因子：
16.6
作者：
Acedo, Joaquin Navajas;Voas, Matthew G.;Piotrowski, Tatjana
通讯作者：
Piotrowski, Tatjana
影响因子：
2.7
作者：
Grimsley-Myers CM;Sipe CW;Wu DK;Lu X
通讯作者：
Lu X