The regulation of c-myc by growth signals.
The regulation of c-myc by growth signals.
复制标题
生长信号对 c-myc 的调节。
DOI：
10.1007/978-3-642-69860-6_22
复制
发表时间：
1984
影响因子：
--
通讯作者：
P. Leder
中科院分区：
文献类型：
--
作者：
K. Kelly;B. Cochran;C. Stiles;P. Leder
C-myc mRNA是一种与细胞周期相关的转录本，其诱导受启动增殖反应第一阶段的药物调节。具体地说，在淋巴细胞与Ip多糖或刀豆蛋白A或成纤维细胞与血小板衍生生长因子(PDGF)孵育后一至三小时内，c-myc mRNA水平在10至40倍之间增加。这种c-myc的诱导不需要合成新的蛋白质种类，因此直接受到成纤维细胞中PDGF结合和淋巴细胞中有丝分裂原结合后立即发生的生化事件的调节。在与细胞周期同步的成纤维细胞中，c-myc基因的表达水平在G0/G1期早期最高，进入S期时下降到静止水平。因此，c-myc RNA是一种最大半衰期为3小时的不稳定转录本。最后，我们的实验提供了将两个癌基因的作用放在一个层次中的数据：c-sis，假定的PDGF结构基因，调节c-myc的表达。
c-myc mRNA is a cell-cycle associated transcript whose induction is regulated by agents that initiate the first phase of a proliferative response. Specifically, c-myc mRNA levels are increased between 10 and 40 fold within one to three hours after incubation of lymphocytes with 1ipopolysaccharide or Concanavalin A or fibroblasts with platelet-derived growth factor (PDGF). This induction of c-myc does not require the synthesis of new protein species and therefore is regulated directly by the biochemical events that immediately follow PDGF binding in fibroblasts and mitogen binding in lymphocytes. In fibroblasts that have been synchronized with respect to the cell-cycle by a short incubation in PDGF, c-myc mRNA levels are maximal in early G0/G1 and diminish to a quiescent level by the time the cells enter the S phase. Thus, c-myc RNA is a labile transcript with a maximal half-life of three hours. Finally, our experiments provide data that places the action of two oncogenes in a hierarchy: c-sis, the putative structural gene for PDGF, regulates the expression of c-myc.
影响因子：
56.9
作者：
DOOLITTLE, RF;HUNKAPILLER, MW;ANTONIADES, HN
通讯作者：
ANTONIADES, HN