Trabecular Bone Structures in the Edentulous Diastema of Osteoporotic Sheep
Trabecular Bone Structures in the Edentulous Diastema of Osteoporotic Sheep
复制标题
骨质疏松绵羊无牙牙间隙的骨小梁结构
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
R. Haas
中科院分区：
文献类型：
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作者：
G. Dvorak;R. Gruber;Christian D. Huber;J. Goldhahn;G. Zanoni;D. Salaberger;G. Watzek;R. Haas
无牙绵羊纵隔是种植学研究的合适区域。由于独特的胚胎起源和机械负荷，无牙间隔对骨质疏松的反应可能不同于含牙区域。为了验证这一假设，我们让老年绵羊接受卵巢切除、钙/维生素D限制饮食和甲基强的松龙注射。成年对照羊仍未接受治疗。结构参数和骨密度分别由微型计算机断层扫描和常规计算机断层扫描确定。我们报告说，间质中的骨小梁微结构没有分解代谢的变化。相比之下，骨质疏松绵羊上颌骨前磨牙区域的骨小梁密度降低，结构相应恶化。这些结果表明，骨质疏松时，无牙间隔的上颌骨小梁骨对牙齿所在部位发生的分解代谢变化没有反应。我们的发现表明，在临床前研究的计划中，必须考虑区域解剖结构域，同时考虑到骨质疏松的变化。
The edentulous ovine diastema represents a suitable region for implantological research. Due to distinctive embryonic origin and mechanical loading, the edentulous diastema may respond differently to osteoporosis than tooth-bearing areas. To test this assumption, we subjected geriatric sheep to ovariectomy, calcium-/vitamin-D-restricted diet, and methylprednisolone administration. Adult control sheep remained untreated. Structural parameters and bone mineral density were determined by microcomputed tomography and conventional computed tomography, respectively. We report that the trabecular microstructure in the diastema was preserved from catabolic changes. In contrast, the premolar maxillary region of osteoporotic sheep had diminished trabecular bone mineral density, with the corresponding structural deteriorations. These results suggest that maxillary trabecular bone of the edentulous diastema does not respond to catabolic changes which occur in the tooth-bearing area in osteoporosis. Our findings imply that regional anatomic domains must be considered in the planning of pre-clinical studies, taking osteoporotic changes into account.
影响因子：
4.1
作者：
RIGGS, BL;MELTON, LJ
通讯作者：
MELTON, LJ
影响因子：
4.3
作者：
Hildebolt, CF;Pilgram, TK;Civitelli, R
通讯作者：
Civitelli, R